NDLI: Sexually Dimorphic SCAMP1 Expression in the Forebrain Motor Pathway for Song Production of Juvenile Zebra Finches

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Sexually Dimorphic SCAMP1 Expression in the Forebrain Motor Pathway for Song Production of Juvenile Zebra Finches

Content Provider	PubMed Central
Author	Tang, Yu Ping Peabody, Camilla Tomaszycki, Michelle L. Wade, Juli
Copyright Year	2007
Abstract	Mechanisms regulating sexual differentiation of the zebra finch song system are not well understood. The present study was designed to more fully characterize secretory carrier membrane protein 1 (SCAMP1), which was identified in a cDNA microarray screen as showing increased expression in the forebrains of developing male compared with female zebra finches. We completed the sequence of the open reading frame and used in situ hybridization to compare mRNA in song control regions of juvenile (25-day-old) individuals. Expression was significantly greater in the HVC (used as a proper name) and robust nucleus of the arcopallium (RA) in males than in females. Immunohistochemistry revealed that SCAMP1 protein is also expressed in these two brain regions, and qualitatively appears greater in males. Western analysis confirmed that the protein is increased in the telencephalon of males when compared with females at 25 days of age. These results are consistent with the idea that SCAMP1 is involved in masculinization of these brain areas, perhaps facilitating the survival of cells within them.
Related Links	http://dx.doi.org/10.1002/dneu.20354
Starting Page	474
File Format	PDF
ISSN	1932846X
e-ISSN	1932846X
Journal	Developmental neurobiology
Issue Number	4
Volume Number	67
Language	English
Publisher Date	2007-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience Developmental Neuroscience

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