NDLI: Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

Content Provider	PubMed Central
Author	La, Gruta Nicole L. Rothwell, William T. Tania, Cukalac Swan, Natasha G. Valkenburg, Sophie A. Kedzierska, Katherine Thomas, Paul G. Doherty, Peter C. Turner, Stephen J.
Abstract	CD8+ T cell responses to viral infection are characterized by the emergence of dominant and subdominant CTL populations. The immunodominance hierarchies of these populations are highly reproducible for any given spectrum of virus-induced peptide-MHCI complexes and are likely determined by multiple factors. Recent studies demonstrate a direct correlation between naive epitope-specific CD8+ T cell precursor (CTLp) frequency and the magnitude of the response after antigen challenge. Thus, the number of available precursors in the naive pool has emerged as a key predictor of immunodominance. In contrast to this, we report here no consistent relationship between CTLp frequency and the subsequent magnitude of the immune response for 4 influenza virus–derived epitopes following intranasal infection of mice with influenza A virus. Rather, the characteristic, antigen-driven T cell immunodominance hierarchy was determined by the extent of recruitment from the available pool of epitope-specific precursors and the duration of their continued expansion over the course of the infection. These findings suggest possibilities for enhancing protective immune memory by maximizing both the size and diversity of typically subdominant T cell responses through rational vaccine design.
Related Links	http://dx.doi.org/10.1172/jci41538
Ending Page	1894
Page Count	10
Starting Page	1885
File Format	PDF
ISSN	00219738
e-ISSN	15588238
Journal	The Journal of Clinical Investigation
Issue Number	6
Volume Number	120
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2010-06-01
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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