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| Content Provider | PubMed Central |
|---|---|
| Author | Purcell, Lisa A. Leitao, Ricardo Ono, Takeshi Yanow, Stephanie K. Pradel, Gabriele Spithill, Terry W. Rodriguez, Ana |
| Copyright Year | 2009 |
| Abstract | The completion of the Plasmodium (malaria) life cycle in the mosquito requires the parasite to traverse first the midgut and later the salivary gland epithelium. We have identified a putative kinase related protein (PKRP) that is predicted to be an atypical protein kinase, which is conserved across many species of Plasmodium. The pkrp gene encodes a RNA of about 5,300 nucleotides that is expressed as a 90 kDa protein in sporozoites. Targeted disruption of the pkrp gene in Plasmodium berghei, a rodent model of malaria, compromises the ability of parasites to infect different tissues within the mosquito host. Early infection of mosquito midgut is reduced by 58-71%, midgut oocyst production is reduced by 50-90% and those sporozoites that are produced are defective in their ability to invade mosquito salivary glands. Midgut sporozoites are not morphologically different from wild type parasites by electron microscopy. Some sporozoites that emerged from oocysts were attached to the salivary glands but most were found circulating in the mosquito hemocoel. Our findings indicate that a signaling pathway involving PbPKRP regulates the level of Plasmodium infection in the mosquito midgut and salivary glands. |
| Related Links | http://dx.doi.org/10.1016/j.ijpara.2010.02.010 |
| Starting Page | 979 |
| File Format | |
| ISSN | 18790135 |
| e-ISSN | 18790135 |
| Journal | International journal for parasitology |
| Issue Number | 8 |
| Volume Number | 40 |
| Language | English |
| Publisher Date | 2010-07-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology |
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