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| Content Provider | PubMed Central |
|---|---|
| Author | Dai, C. Y. Yu, M. L. Chang, W. Y. Tseng, C. H. Hou, C. Lin, Z. Y. Chen, S. C. Hsieh, M. Y. Wang, L. Y. Tsai, J. F. Chuang, W. L. |
| Abstract | The prevalence of TT virus (TTV) and GB virus-C/hepatitis G virus (GBV-C/HGV) infection and the association with raised liver function tests in 546 Taiwanese with negative HBsAg, anti-HCV and HCV RNA was elucidated. They were tested for serum alanine aminotransferase (ALT), GBV-C/HGV RNA, anti-envelope protein 2 antibody (anti-E2) and TTV DNA. Direct sequencing and phylogenetic analyses were performed on 58 isolates for TTV genotype determination. The prevalence of TTV DNA, GBV-C/HGV RNA, anti-E2 and over all GBV-C/HGV exposure was 24.9, 3.4, 8.2 and 11.1%, respectively. Using uni- and multi-variate analyses, male gender and TTV viremia were associated significantly with raised ALT values. Sixty-nine percent of TTV isolates were deduced to be TTV genotype 1 and they had significantly lower mean age than genotype non-1 isolates. In the population, raised ALT may be related to male gender and be attributable to TTV infection but not to GBV-C/HGV among individuals with no evidence of current HBV and HCV infection. TTV genotype 1 is the most prevalent genotype and associated with younger age. |
| Starting Page | 307 |
| File Format | |
| ISSN | 09502688 |
| Journal | Epidemiology and Infection |
| Issue Number | 2 |
| Volume Number | 129 |
| Language | English |
| Publisher | Cambridge University Press |
| Publisher Date | 2002-10-01 |
| Access Restriction | Open |
| Rights Holder | Cambridge University Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology |
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