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  1. Cancer Metastasis Reviews
  2. Year: 2010, Volume: 29
  3. Year: 2010, Volume: 29, Issue: 2
  4. Why not treat human cancer with interleukin-1 blockade?
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Year: 2016, Volume: 35
Year: 2015, Volume: 34
Year: 2014, Volume: 33
Year: 2013, Volume: 33
Year: 2013, Volume: 32
Year: 2012, Volume: 31
Year: 2011, Volume: 30
Year: 2010, Volume: 29
Year: 2010, Volume: 29, Issue: 4
Year: 2010, Volume: 29, Issue: 3
Year: 2010, Volume: 29, Issue: 2
Senescent cells as a source of inflammatory factors for tumor progression
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
Why not treat human cancer with interleukin-1 blockade?
Year: 2010, Volume: 29, Issue: 1
Year: 2009, Volume: 28
Year: 2008, Volume: 27
Year: 2007, Volume: 26
Year: 2006, Volume: 25
Year: 2005, Volume: 24

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Why not treat human cancer with interleukin-1 blockade?

Content Provider PubMed Central
Author Dinarello, Charles A.
Abstract The clinical successes of targeting angiogenesis provide a basis for trials of interleukin-1 (IL-1) blockade and particularly anti-IL-1β as an add-on therapy in human metastatic disease. In animal studies for over 20 years, IL-1 has been demonstrated to increase adherence of tumor cells to the endothelium in vitro, and administration of IL-1 to mice increases the number of metastatic colonies and tumor growth. Importantly, reducing endogenous IL-1 activity, particularly IL-1β, with the naturally occurring IL-1 receptor antagonist (IL-1Ra) reduces both metastasis as well as tumor burden. Inhibition of IL-1 activity prevents in vivo blood vessel formation induced by products released from hypoxic macrophages or vascular endothelial cell growth factor itself. Mice deficient in IL-1β do not form blood vessels in matrigels embedded with vascular endothelial cell growth factor or containing products of macrophages. Recombinant IL-1Ra (anakinra) has been administered to over 1,000 patients with septic shock resulting in a consistent reduction in all-cause 28-day mortality. Approved for treatment of rheumatoid arthritis, anakinra has a remarkable safety record. Anakinra resulted in decreased blood vessels in the pannus of affected joints in patients with rheumatoid arthritis. Neutralizing monoclonal antibodies to IL-1β and a soluble receptor to IL-1 are approved for treating chronic inflammatory diseases. Given the availability of three therapeutic agents for limiting IL-1 activity, the safety of blocking IL-1, and the clear benefit of blocking IL-1 activity in animal models of metastasis and angiogenesis, clinical trials of IL-1 blockade should be initiated, particularly as an add-on therapy of patients receiving antiangiogenesis-based therapies.
Related Links http://dx.doi.org/10.1007/s10555-010-9229-0
Ending Page 329
Page Count 13
Starting Page 317
File Format PDF
ISSN 01677659
e-ISSN 15737233
Journal Cancer Metastasis Reviews
Issue Number 2
Volume Number 29
Language English
Publisher Springer US
Publisher Date 2010-06-01
Access Restriction Open
Rights Holder Springer US
Subject Keyword Cancer Research Oncology Research in Higher Education
Content Type Text
Resource Type Article
Subject Cancer Research Oncology
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