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| Content Provider | PubMed Central |
|---|---|
| Author | Bon, B. Houze, S. Talabani, H. Magne, D. Belkadi, G. Develoux, M. Senghor, Y. Chandenier, J. Ancelle, T. Hennequin, C. |
| Copyright Year | 2010 |
| Abstract | Diagnosis of strongyloidiasis using stool examination remains unsatisfactory due to the lack of sensitivity and fastidious techniques. In this work, we investigated the value of an anti-Strongyloides IgG enzyme immunoassay (EIA), using a panel of 207 sera retrospectively collected from patients with definitive diagnoses of strongyloidiasis (n = 57), other helminthic infections (n = 46), eosinophilia without parasitic infection diagnosis (n = 54), and digestive disturbances following a tropical journey (n = 30) and from 20 negative controls. By following a receiver operating characteristic (ROC) curve analysis, it was possible to optimize the test to reach a sensitivity of 91.2% and a specificity of 93.3%, with 92.8% of patients correctly classified. Considering the incidence of strongyloidiasis diagnosed in our own laboratory, the negative predictive value was calculated at 99.9%. In conclusion, this test is very rapid and easy to perform and may be valuable for diagnosis of strongyloidiasis both in cases where the infection is unrevealed by a parasitological stool examination and in patients at risk for severe clinical forms, such as patients receiving immunosuppressive therapy. |
| Related Links | http://dx.doi.org/10.1128/jcm.02364-09 |
| Ending Page | 1719 |
| Page Count | 4 |
| Starting Page | 1716 |
| File Format | |
| ISSN | 00951137 |
| e-ISSN | 1098660X |
| Journal | Journal of Clinical Microbiology |
| Issue Number | 5 |
| Volume Number | 48 |
| Language | English |
| Publisher | American Society for Microbiology (ASM) |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology (ASM) |
| Subject Keyword | Microbiology (medical) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) |
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