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| Content Provider | PubMed Central |
|---|---|
| Author | Li, Lin He, Lili Tan, Suiyi Guo, Xinhua Lu, Hong Qi, Zhi Pan, Chungen An, Xiuli Jiang, Shibo Liu, Shuwen |
| Copyright Year | 2010 |
| Abstract | Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual transmission of HIV is urgently needed. Here we report that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) exhibits potent antiviral activity against a broad spectrum of human immunodeficiency virus type 1 (HIV-1) isolates with different genotypes and biotypes. Its antiviral activity is correlated with the percentages of the chemically modified and unmodified lysines and arginines in OVA. HP-OVA inhibits HIV-1 fusion and entry through multiple mechanisms of action, including (i) blocking gp120 binding to CD4 and (ii) interfering with gp41 six-helix bundle formation. Because of the widespread availability and established safety profile of OVA, HP-OVA has good potential to be developed as an effective, safe, and affordable microbicide for prevention of HIV sexual transmission. |
| Related Links | http://dx.doi.org/10.1128/aac.01046-09 |
| Ending Page | 1711 |
| Page Count | 12 |
| Starting Page | 1700 |
| File Format | |
| ISSN | 00664804 |
| e-ISSN | 10986596 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Issue Number | 5 |
| Volume Number | 54 |
| Language | English |
| Publisher | American Society for Microbiology (ASM) |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology (ASM) |
| Subject Keyword | Pharmacology (medical) Pharmacology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) |
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