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Dangerous Allergens: Why Some Allergens are Bad Actors
| Content Provider | PubMed Central |
|---|---|
| Author | Georas, Steve N. Rezaee, Fariba Lerner, Laurie Beck, Lisa |
| Copyright Year | 2010 |
| Abstract | Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway epithelial cells and dendritic cells are key components of the innate immune system in the nose and lung and are now known to be intimately involved in allergen recognition and in modulating allergic immune responses. Here we review current thinking about how these two key cell types sense and respond to inhaled allergens, and emphasize how an understanding of “allergic innate immunity” can translate into new thinking about mechanisms of allergen sensitization and potentially lead to new therapeutic targets. |
| Related Links | http://dx.doi.org/10.1007/s11882-010-0090-6 |
| Ending Page | 98 |
| Page Count | 7 |
| Starting Page | 92 |
| File Format | |
| ISSN | 15297322 |
| e-ISSN | 15346315 |
| Journal | Current allergy and asthma reports |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher Date | 2010-03-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology and Allergy Pulmonary and Respiratory Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Immunology |
