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The inflammatory network: bridging senescent stroma and epithelial tumorigenesis
| Content Provider | PubMed Central |
|---|---|
| Author | Shan, Weiwei Yang, Gong Liu, Jinsong |
| Abstract | Cellular senescence or cellular aging, defined by permanent cell cycle arrest, is well known for its evolutionary advantage in protecting the organism from developing cancer; however, it is also acknowledged that aged stromal cells can significantly expedite epithelial tumorigenesis, although exactly how they function to augment tumor formation remains elusive. Recent evidence suggests that this tumor-promoting effect is likely mediated by diffusible pro-inflammatory molecules synthesized and released by senescent stromal fibroblasts, acting in a paracrine fashion on adjacent tumor epithelium. Mobilization of the inflammatory network by senescent fibroblasts has bifurcated roles on the epithelial and stromal compartments, converging on the promotion of epithelial tumorigenesis. A thorough understanding of the regulatory mechanisms underlying these events may lead to improved approaches in cancer treatment. |
| Starting Page | 4044 |
| File Format | |
| ISSN | 10939946 |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Volume Number | 14 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |
