NDLI: Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+

Content Provider	PubMed Central
Author	Forster, H. V. Smith, C. A.
Copyright Year	2010
Abstract	The major objective of this review is to evaluate existing information and reach conclusions regarding whether there is interaction between Pco2/H+ stimulation of carotid (peripheral) and intracranial (central) chemoreceptors. Interaction is defined as a ventilatory response to simultaneous changes in the degree of Pco2/H+ stimulation of both chemoreceptors that is greater (hyperadditive) or less (hypoadditive) than the sum of the responses when stimulation of each set of chemoreceptors is individually altered. Simple summation of the simultaneous changes in stimuli results in no interaction (i.e., additive interaction). Knowledge of the nature of central/peripheral interaction is crucial for determining the physiological significance of newer models of ventilatory control based on recent neuroanatomic observations of the circuitry of key elements of the ventilatory control system. In this review, we will propose that these two sets of receptors are not functionally separate but rather that they are dependent on one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the peripheral chemoreceptors and possibly other breathing-related reflex afferents as well. The short format of this minireview demands that we be somewhat selective in developing our ideas. We will briefly discuss the limitations of experiments used to study CO2/H+ sensitivity and interaction to date, traditional views of the relative contributions of peripheral and central chemoreceptors to CO2/H+ sensitivity, the evidence for and against different types of interaction, and the effect of tonic carotid chemoreceptor afferent activity on central control mechanisms.
Related Links	http://dx.doi.org/10.1152/japplphysiol.01059.2009
Ending Page	994
Page Count	6
Starting Page	989
File Format	PDF
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	4
Volume Number	108
Language	English
Publisher	American Physiological Society
Publisher Date	2010-04-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology (medical) Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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