NDLI: Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells

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Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells

Content Provider	PubMed Central
Author	Andukuri, Adinarayana Minor, Will P. Kushwaha, Meenakshi Anderson, Joel M. Jun, Ho-wook
Copyright Year	2009
Abstract	The goal of this study is to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles (PAs) through a solvent evaporation technique. Three PAs, one containing the Tyr-Ile-Gly-Ser-Arg (YIGSR) ligand, second containing the Val-Ala-Pro-Gly (VAPG) ligand, and a third without cell adhesive ligands were developed. Cell adhesion and spreading were evaluated by a PicoGreen-DNA assay and Live/Dead assay respectively. Our results show that PA-YIGSR significantly enhances HUVEC adhesion (26704±2708) spreading (84 ±8%), and proliferation (50±2%) when compared to other PAs. PA-VAPG and PA-YIGSR showed significantly greater AoSMC adhesion when compared to PA-S. PA-VAPG also showed significantly greater spreading of AoSMCs (63 ±11%) when compared with other PAs. Also, all the PAs showed significantly reduced platelet adhesion when compared with collagen I (control). These findings would facilitate the development of novel vascular grafts, heart valves, and cell based therapies for cardiovascular diseases.
Related Links	http://dx.doi.org/10.1016/j.nano.2009.09.004
Ending Page	297
Page Count	9
Starting Page	289
File Format	PDF
ISSN	15499634
e-ISSN	15499642
Journal	Nanomedicine : nanotechnology, biology, and medicine
Issue Number	2
Volume Number	6
Language	English
Publisher Date	2010-04-01
Access Restriction	Open
Subject Keyword	Molecular Medicine Materials Science(all) Medicine (miscellaneous) Bioengineering Pharmaceutical Science Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Molecular Medicine Bioengineering Biomedical Engineering Pharmaceutical Science

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