NDLI: Pore architecture and ion sites in acid sensing ion channels and P2X receptors

Content Provider	PubMed Central
Author	Gonzales, Eric B. Kawate, Toshimitsu Eric, Gouaux
Abstract	Acid-sensing ion channels are proton-activated, sodium-selective channels composed of three subunits and members of the superfamily of epithelial sodium channels, mechanosensitive and FMRF peptide-gated ion channels. These ubiquitous eukaryotic ion channels play essential roles in biological activities as diverse as sodium homeostasis, taste, and pain. Despite their crucial roles in biology and their unusual trimeric subunit stoichiometry, there is little knowledge of the structural and chemical principles underlying their ion channel architecture and ion binding sites. Here we describe the structure of a functional acid sensing ion channel in a desensitized state at 3 Å resolution, the location and composition of the ~8 Å ‘thick’ desensitization gate, and the trigonal antiprism coordination of cesium ions bound in the extracellular vestibule. Comparison of the acid sensing ion channel structure with the ATP-gated P2×4 receptor reveals similarity in pore architecture and aqueous vestibules, suggesting unanticipated yet common structural and mechanistic principles.
Related Links	http://dx.doi.org/10.1038/nature08218
Ending Page	604
Page Count	6
Starting Page	599
File Format	PDF
ISSN	00280836
e-ISSN	14764687
Journal	Nature
Issue Number	7255
Volume Number	460
Language	English
Publisher Date	2009-07-30
Access Restriction	Open
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Optical control of trimeric P2X receptors and acid-sensing ion channels

Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)

Acid-sensing ion channels interact with and inhibit BK K+ channels

Optical control of trimeric P2X receptors and acid-sensing ion channels

Ion access pathway to the transmembrane pore in P2X receptor channels

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Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).

Pore architecture and ion sites in acid sensing ion channels and P2X receptors

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