NDLI: Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking

Content Provider	PubMed Central
Author	Kumaresan, Vidhya Yuan, Menglu Yee, Judy Famous, Katie R. Anderson, Sharon M. Schmidt, Heath D. Pierce, R. Christopher
Abstract	Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior. In the present experiments, rats were trained to self-administer cocaine under fixed ratio (for cocaine priming-induced reinstatement) or second order (for cocaine cue-induced reinstatement) schedules of reinforcement. Lever pressing was then extinguished followed by a reinstatement phase where operant responding was promoted by either cocaine itself or cocaine-associated light cues. Results indicated that systemic administration of the mGluR5 antagonists 2-Methyl-6-(phenylethynyl)pyridine (MPEP: 1 and 3 mg/kg i.p.) or 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP: 0.1 and 1 mg/kg i.p.) dose-dependently attenuated reinstatement of drug seeking induced by a systemic priming injection of 10 mg/kg cocaine. Systemic administration of MTEP (0.1 and 1 mg/kg i.p) also dose-dependently attenuated cocaine cue-induced reinstatement of drug seeking. Systemic administration of neither MPEP nor MTEP influenced the reinstatement of sucrose seeking, which indicates that the effects of these compounds on cocaine seeking were reinforcer specific. Additionally, administration of MPEP (1 μg/0.5μl) into the nucleus accumbens shell, a brain region that plays a critical role in cocaine seeking, attenuated cocaine priming-induced reinstatement of drug seeking. These results add to a growing literature indicating that mGluR antagonists attenuate the reinstatement of cocaine seeking. Importantly, the current findings also suggest that activation of mGluR5s specifically in the nucleus accumbens shell promotes the reinstatement of cocaine seeking.
Related Links	http://dx.doi.org/10.1016/j.bbr.2009.03.039
Ending Page	244
Page Count	7
Starting Page	238
File Format	PDF
ISSN	01664328
e-ISSN	18727549
Journal	Behavioural brain research
Issue Number	2
Volume Number	202
Language	English
Publisher Date	2009-09-01
Access Restriction	Open
Subject Keyword	Behavioral Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Behavioral Neuroscience

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