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| Content Provider | PubMed Central |
|---|---|
| Author | Endler, Lukas Rodriguez, Nicolas Nick, Juty Chelliah, Vijayalakshmi Camille, Laibe Li, Chen Le Novère, Nicolas |
| Copyright Year | 2009 |
| Abstract | A key component of any synthetic biology effort is the use of quantitative models. These models and their corresponding simulations allow optimization of a system design, as well as guiding their subsequent analysis. Once a domain mostly reserved for experts, dynamical modelling of gene regulatory and reaction networks has been an area of growth over the last decade. There has been a concomitant increase in the number of software tools and standards, thereby facilitating model exchange and reuse. We give here an overview of the model creation and analysis processes as well as some software tools in common use. Using markup language to encode the model and associated annotation, we describe the mining of components, their integration in relational models, formularization and parametrization. Evaluation of simulation results and validation of the model close the systems biology ‘loop’. |
| Related Links | http://dx.doi.org/10.1098/rsif.2009.0035.focus |
| Starting Page | 405 |
| File Format | |
| ISSN | 17425689 |
| e-ISSN | 17425662 |
| Journal | Journal of the Royal Society Interface |
| Issue Number | Suppl 4 |
| Volume Number | 6 |
| Language | English |
| Publisher | The Royal Society |
| Publisher Date | 2009-08-06 |
| Access Restriction | Open |
| Rights Holder | The Royal Society |
| Subject Keyword | Biotechnology Biophysics Biochemistry Bioengineering Biomaterials Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Biomaterials Biophysics Bioengineering Biomedical Engineering Biotechnology |
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