NDLI: A novel in vivo method for quantifying the interfacial biochemical bond strength of bone implants

Content Provider	PubMed Central
Author	Sul, Young-taeg Johansson, Carina Albrektsson, Tomas
Copyright Year	2010
Abstract	Quantifying the in vivo interfacial biochemical bond strength of bone implants is a biological challenge. We have developed a new and novel in vivo method to identify an interfacial biochemical bond in bone implants and to measure its bonding strength. This method, named biochemical bond measurement (BBM), involves a combination of the implant devices to measure true interfacial bond strength and surface property controls, and thus enables the contributions of mechanical interlocking and biochemical bonding to be distinguished from the measured strength values. We applied the BBM method to a rabbit model, and observed great differences in bone integration between the oxygen (control group) and magnesium (test group) plasma immersion ion-implanted titanium implants (0.046 versus 0.086 MPa, n=10, p=0.005). The biochemical bond in the test implants resulted in superior interfacial behaviour of the implants to bone: (i) close contact to approximately 2 μm thin amorphous interfacial tissue, (ii) pronounced mineralization of the interfacial tissue, (iii) rapid bone healing in contact, and (iv) strong integration to bone. The BBM method can be applied to in vivo experimental models not only to validate the presence of a biochemical bond at the bone–implant interface but also to measure the relative quantity of biochemical bond strength. The present study may provide new avenues for better understanding the role of a biochemical bond involved in the integration of bone implants.
Related Links	http://dx.doi.org/10.1098/rsif.2009.0060
Starting Page	81
File Format	PDF
ISSN	17425662
e-ISSN	17425662
Journal	Journal of the Royal Society Interface
Issue Number	42
Volume Number	7
Language	English
Publisher	The Royal Society
Publisher Date	2010-01-06
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biomaterials Biophysics Bioengineering Biomedical Engineering Biotechnology

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