NDLI: CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

Content Provider	PubMed Central
Author	Zlotoff, Daniel A. Sambandam, Arivazhagan Logan, Theodore D. Bell, J. Jeremiah Schwarz, Benjamin A. Avinash, Bhandoola
Abstract	T lymphopoiesis requires settling of the thymus by bone marrow–derived precursors throughout adult life. Progenitor entry into the thymus is selective, but the molecular basis of this selectivity is incompletely understood. The chemokine receptor CCR9 has been demonstrated to be important in this process. However, progenitors lacking CCR9 can still enter the thymus, suggesting a role for additional molecules. Here we report that the chemokine receptor CCR7 is also required for efficient thymic settling. CCR7 is selectively expressed on bone marrow progenitors previously shown to have the capacity to settle the thymus, and CCR7−/− progenitors are defective in settling the thymus. We further demonstrate that CCR7 sustains thymic settling in the absence of CCR9. Mice deficient for both CCR7 and CCR9 have severe reductions in the number of early thymic progenitors, and in competitive assays CCR7−/−CCR9−/− double knockout progenitors are almost completely restricted from thymic settling. However, these mice possess near-normal thymic cellularity. Compensatory expansion of intrathymic populations can account for at least a part of this recovery. Together our results illustrate the critical role of chemokine receptor signaling in thymic settling and help to clarify the cellular identity of the physiologic thymic settling progenitors.
Related Links	http://dx.doi.org/10.1182/blood-2009-08-237784
Ending Page	1905
Page Count	9
Starting Page	1897
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	10
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-03-11
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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