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| Content Provider | PubMed Central |
|---|---|
| Author | Manapat, Michael L. Chen, Irene A. Nowak, Martin A. |
| Abstract | Template-directed polymerization of nucleotides is believed to be a pathway for the replication of genetic material in the earliest cells. We assume that activated monomers are produced by prebiotic chemistry. These monomers can undergo spontaneous polymerization, a system that we call “prelife.” Adding template-directed polymerization changes the equilibrium structure of prelife if the rate constants meet certain criteria. In particular, if the basic reproductive ratio of sequences of a certain length exceeds one, then those sequences can attain high abundance. Furthermore, if many sequences replicate, then the longest sequences can reach high abundance even if the basic reproductive ratios of all sequences are less than one. We call this phenomenon “subcritical life.” Subcritical life suggests that sequences long enough to be ribozymes can become abundant even if replication is relatively inefficient. Our work on the evolution of replication has interesting parallels to infection dynamics. Life (replication) can be seen as an infection of prelife. |
| Related Links | http://dx.doi.org/10.1016/j.jtbi.2009.12.020 |
| Ending Page | 327 |
| Page Count | 11 |
| Starting Page | 317 |
| File Format | |
| ISSN | 00225193 |
| e-ISSN | 10958541 |
| Journal | Journal of theoretical biology |
| Issue Number | 3 |
| Volume Number | 263 |
| Language | English |
| Publisher Date | 2010-04-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Modelling and Simulation Statistics and Probability Immunology and Microbiology(all) Applied Mathematics Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Statistics and Probability Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences Modeling and Simulation |
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