NDLI: In vivo Biodistribution and Clearance Studies using Multimodal ORMOSIL Nanoparticles

Content Provider	PubMed Central
Author	Kumar, Rajiv Roy, Indrajit Ohulchanskky, Tymish Y. Vathy, Lisa A. Bergey, Earl J. Sajjad, Munawwar Prasad, Paras N.
Abstract	Successful translation of the use of nanoparticles from laboratories to clinics requires exhaustive and elaborate studies involving the biodistribution, clearance and biocompatibility of nanoparticles for in vivo biomedical applications. We report here the use of multimodal organically modified silica (ORMOSIL) nanoparticles for in vivo bioimaging, biodistribution, clearance and toxicity studies. We have synthesized ORMOSIL nanoparticles with diameters of 20-25 nm, conjugated with near infra-red (NIR) fluorophores and radiolabelled them with 124I, for optical and PET imaging in vivo. The biodistribution of the non targeted nanoparticles was studied in non-tumored nude mice by optical fluorescence imaging, as well by measuring the radioactivity from harvested organs. Biodistribution studies showed a greater accumulation of nanoparticles in liver, spleen and stomach than in kidney, heart and lungs. The clearance studies carried out over a period of 15 days indicated hepatobiliary excretion of the nanoparticles. Selected tissues were analyzed for any potential toxicity by histological analysis, which confirmed the absence of any adverse effect or any other abnormalities in the tissues. The results demonstrate that these multimodal nanoparticles have potentially ideal attributes for use as biocompatible probes for in vivo imaging.
Related Links	http://dx.doi.org/10.1021/nn901146y
Ending Page	708
Page Count	10
Starting Page	699
File Format	PDF
ISSN	19360851
e-ISSN	1936086X
Journal	ACS nano
Issue Number	2
Volume Number	4
Language	English
Publisher Date	2010-02-23
Access Restriction	Open
Subject Keyword	Engineering(all) Physics and Astronomy(all) Materials Science(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Physics and Astronomy Engineering

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