NDLI: Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis

Please wait, while we are loading the content...

Year: 2015, Volume: 17

Year: 2014, Volume: 16

Year: 2013, Volume: 15

Year: 2012, Volume: 14

Year: 2011, Volume: 13

Year: 2010, Volume: 12

Year: 2010, Volume: 12, Issue: 14-15

Year: 2010, Volume: 12, Issue: 12-13

Year: 2010, Volume: 12, Issue: 11

Year: 2010, Volume: 12, Issue: 10

Year: 2010, Volume: 12, Issue: 8-9

Year: 2010, Volume: 12, Issue: 7

Year: 2010, Volume: 12, Issue: 6

Year: 2010, Volume: 12, Issue: 5

Year: 2010, Volume: 12, Issue: 3

Year: 2010, Volume: 12, Issue: 2

Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis

Year: 2010, Volume: 12, Issue: 1

Year: 2009, Volume: 11

Year: 2008, Volume: 10

Year: 2007, Volume: 9

Year: 2006, Volume: 8

Year: 2004, Volume: 6

Year: 2003, Volume: 5

Year: 2001, Volume: 3

Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis

Content Provider	PubMed Central
Author	Santic, Marina Gordana, Pavokovic Jones, Snake Asare, Rexford Abu, Kwaik Yousef
Copyright Year	2009
Abstract	Francisella tularensis induces apoptosis within macrophages but the temporal and spatial modulation through activation of caspase-1, caspase-3, and the anti-apoptosis nuclear transcription factor B (NF-κB) is not known. Whether escape of the bacteria into the cytosol is sufficient and/or essential for activation of NF-κB is not known. Our results show that F. tularensis subsp. novicida induces sustained nuclear translocation of NF-κB at early time points after infection of human monocytes derived macrophages (hMDMs). The sustained nuclear translocation of NF-κB is defective in the iglC mutant that fails to escape into the cytosol of macrophages. Nuclear translocation of NF-κB by the wild type strain is abolished upon treatment with the NF-κB inhibitor caffein acid phenyl ester. While the wild type strain triggers caspase-3 and caspase-1 activation by 6 h post-infection the iglC mutant is defective in triggering both caspases. In hMDMs treated with the apoptosis-inducing agent, staurosporin, there is an induction of cell death in the iglC mutant-infected macrophages despite reduced frequency of caspase-1 and caspase-3 activity. The wt-infected macrophages are resistant to cell death-induced agent. We conclude that although caspase-1 and capsase-3 are triggered within F. tularensis-infected hMDMs during early stages of infection, cell death is delayed, which is correlated with simultaneous activation of NF-κB.
Related Links	http://dx.doi.org/10.1016/j.micinf.2009.11.003
Starting Page	126
File Format	PDF
ISSN	12864579
e-ISSN	1769714X
Journal	Microbes and infection / Institut Pasteur
Issue Number	2
Volume Number	12
Language	English
Publisher Date	2010-02-01
Access Restriction	Open
Subject Keyword	Immunology Microbiology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology Microbiology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in