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| Content Provider | PubMed Central |
|---|---|
| Author | Kawai, Tatsuo Cosimi, A. Benedict Spitzer, Thomas R. Nina, Tolkoff-rubin Suthanthiran, Manikkam Saidman, Susan L. Shaffer, Juanita Preffer, Frederic I. Ding, Ruchuang Sharma, Vijay Fishman, Jay A. Dey, Bimalangshu Ko, Dicken S. C. Hertl, Martin Goes, Nelson B. Wong, Waichi Williams, Winfred W. Colvin, Robert B. Sykes, Megan Sachs, David H. |
| Abstract | Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal function has remained stable for 2.0 to 5.3 years since transplantation. The T cells from these four recipients, tested in vitro, showed donor-specific unresponsiveness and in specimens from allograft biopsies, obtained after withdrawal of immunosuppressive therapy, there were high levels of P3 (FOXP3) messenger RNA (mRNA) but not granzyme B mRNA. |
| Related Links | http://dx.doi.org/10.1056/NEJMoa071074 |
| Starting Page | 353 |
| File Format | |
| ISSN | 15334406 |
| e-ISSN | 15334406 |
| Journal | The New England journal of medicine |
| Issue Number | 4 |
| Volume Number | 358 |
| Language | English |
| Publisher Date | 2008-01-24 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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