NDLI: A New Aspect of the TrkB Signaling Pathway in Neural Plasticity

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A New Aspect of the TrkB Signaling Pathway in Neural Plasticity

Content Provider	PubMed Central
Author	Ohira, K. Hayashi, M.
Copyright Year	2009
Abstract	In the central nervous system (CNS), the expression of molecules is strictly regulated during development. Control of the spatiotemporal expression of molecules is a mechanism not only to construct the functional neuronal network but also to adjust the network in response to new information from outside of the individual, i.e., through learning and memory. Among the functional molecules in the CNS, one of the best-studied groups is the neurotrophins, which are nerve growth factor (NGF)-related gene family molecules. Neurotrophins include NGF, brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and NT-4/5 in the mammal. Among neurotrophins and their receptors, BDNF and tropomyosin-related kinases B (TrkB) are enriched in the CNS. In the CNS, the BDNF-TrkB signaling pathway fulfills a wide variety of functions throughout life, such as cell survival, migration, outgrowth of axons and dendrites, synaptogenesis, synaptic transmission, and remodeling of synapses. Although the same ligand and receptor, BDNF and TrkB, act in these various developmental events, we do not yet understand what kind of mechanism provokes the functional multiplicity of the BDNF-TrkB signaling pathway. In this review, we discuss the mechanism that elicits the variety of functions performed by the BDNF-TrkB signaling pathway in the CNS as a tool of pharmacological therapy.
Related Links	http://dx.doi.org/10.2174/157015909790031210
Ending Page	285
Page Count	10
Starting Page	276
File Format	PDF
ISSN	1570159X
e-ISSN	18756190
Journal	Current Neuropharmacology
Issue Number	4
Volume Number	7
Language	English
Publisher	Bentham Science Publishers Ltd.
Publisher Date	2009-12-01
Access Restriction	Open
Rights Holder	Bentham Science Publishers Ltd.
Subject Keyword	Pharmacology (medical) Pharmacology Neurology Psychiatry and Mental health Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Pharmacology Pharmacology (medical) Psychiatry and Mental Health

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