NDLI: Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing

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Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing

Content Provider	PubMed Central
Author	Schneider, A. Wang, X. Y. Kaplan, D. L. Garlick, J. A. Egles, C.
Abstract	Materials able to deliver topically bioactive molecules represent a new generation of biomaterials. In this article, we describe the use of silk mats, made of electrospun nanoscale silk fibers containing epidermal growth factor (EGF), for the promotion of wound healing processes. In our experiments, we demonstrated that EGF is incorporated into the silk mats and slowly released in a time-dependent manner (25% EGF release in 170 h). We tested these materials using a new model of wounded human skin-equivalents displaying the same structure as human skin and able to heal using the same molecular and cellular mechanisms found in vivo. This human three-dimensional model allows us to demonstrate that the biofunctionalized silk mats, when placed on the wounds as a dressing, aid the healing by increasing the time of wound closure by the epidermal tongue by 90%. The preservation of the structure of the mats during the healing period as demonstrated by electronic microscopy, the biological action of the dressing, as well as the biocompatibility of the silk demonstrate that this biomaterial is a new and very promising material for medical applications, especially for patients suffering from chronic wounds.
Related Links	http://dx.doi.org/10.1016/j.actbio.2008.12.013
Ending Page	2578
Page Count	9
Starting Page	2570
File Format	PDF
ISSN	17427061
e-ISSN	18787568
Journal	Acta biomaterialia
Issue Number	7
Volume Number	5
Language	English
Publisher Date	2009-09-01
Access Restriction	Open
Subject Keyword	Biotechnology Biochemistry Molecular Biology Biomaterials Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Molecular Biology Biomaterials Biomedical Engineering Biotechnology

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