NDLI: MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets

Content Provider	PubMed Central
Author	Sharma, Vineet K. Kumar, Naveen Prakash, Tulika Taylor, Todd D.
Copyright Year	2009
Abstract	Microbial enzymes have many known applications as biocatalysts in biotechnology, agriculture, medical and other industries. However, only a few enzymes are currently employed for such commercial applications. In this scenario, the current onslaught of metagenomic data provides a new unexplored treasure trove of genomic wealth that can not only enhance the enzyme repertoire by the discovery of novel commercially useful enzymes (CUEs) but can also reveal better functional variants for existing CUEs. We prepared a catalogue of CUEs using text mining of PubMed abstracts and other publicly available information, and manually curated the data to identify 510 CUEs. Further, in order to identify novel homologues of these CUEs, we identified potential ORFs in publicly available metagenomic datasets from 10 diverse sources. Using this strategy, we have developed a resource called MetaBioME (http://metasystems.riken.jp/metabiome/) that comprises (i) a database of CUEs and (ii) a comprehensive platform to facilitate homology-based computational identification of novel homologous CUEs from metagenomic and bacterial genomic datasets. Using MetaBioME, we have identified several novel homologues to known CUEs that can potentially serve as leads for further experimental verification.
Related Links	http://dx.doi.org/10.1093/nar/gkp1001
Starting Page	468
File Format	PDF
ISSN	13624962
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	Database issue
Volume Number	38
Language	English
Publisher	Oxford University Press
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets

HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes

Metagenomic approach to explore the enzymes of biotechnological potential for basic and applied studies

MilxXplore: a web-based system to explore large imaging datasets

Protein Geometry Database: a flexible engine to explore backbone conformations and their relationships to covalent geometry

HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes

MetaPath: identifying differentially abundant metabolic pathways in metagenomic datasets

Exploring Metagenomic Enzymes: A Novel Esterase Useful for Short-Chain Ester Synthesis

Fast and Sensitive Alignment of Microbial Whole Genome Sequencing Reads to Large Sequence Datasets on a Desktop PC: Application to Metagenomic Datasets and Pathogen Identification

MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets

Similar Documents

MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets

HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes

Metagenomic approach to explore the enzymes of biotechnological potential for basic and applied studies

MilxXplore: a web-based system to explore large imaging datasets

Protein Geometry Database: a flexible engine to explore backbone conformations and their relationships to covalent geometry

HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes

MetaPath: identifying differentially abundant metabolic pathways in metagenomic datasets

Exploring Metagenomic Enzymes: A Novel Esterase Useful for Short-Chain Ester Synthesis

Fast and Sensitive Alignment of Microbial Whole Genome Sequencing Reads to Large Sequence Datasets on a Desktop PC: Application to Metagenomic Datasets and Pathogen Identification

MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets