NDLI: Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

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Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

Content Provider	PubMed Central
Author	Altmeyer, Matthias Hottiger, Michael O.
Copyright Year	2009
Abstract	Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated nuclear protein, which functions as molecular stress sensor. Reactive oxygen species, responsible for the most plausible and currently acceptable global mechanism to explain the aging process, strongly activate the enzymatic activity of PARP1 and the formation of poly(ADP-ribose) (PAR) from NAD+. Consumption of NAD+ links PARP1 to energy metabolism and to a large number of NAD+-dependent enzymes, such as the sirtuins. As transcriptional cofactor for NF-κB-dependent gene expression, PARP1 is also connected to the immune response, which is implicated in almost all age-related or associated diseases. Accordingly, numerous experimental studies have demonstrated the beneficial effects of PARP inhibition for several age-related diseases. This review summarizes recent findings on PARP1 and puts them in the context of metabolic stress and inflammation in aging.
Related Links	http://dx.doi.org/10.18632/aging.100052
Ending Page	469
Page Count	12
Starting Page	458
File Format	PDF
ISSN	19454589
e-ISSN	19454589
Journal	Aging
Issue Number	5
Volume Number	1
Language	English
Publisher	Impact Journals LLC
Publisher Date	2009-05-01
Access Restriction	Open
Rights Holder	Impact Journals LLC
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Aging

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