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Understanding Measurements of Intestinal Permeability in Healthy Humans with Urine Lactulose and Mannitol Excretion
| Content Provider | PubMed Central |
|---|---|
| Author | Camilleri, Michael Nadeau, Ashley Lamsam, Jesse Nord, Sara Linker Ryks, Michael Burton, Duane Sweetser, Seth Zinsmeister, Alan R. Singh, Ravinder |
| Copyright Year | 2009 |
| Abstract | Our aim was to understand the information from differential two-sugar excretion (2-SE) in measuring intestinal permeability. In a crossover study in 12 healthy volunteers, we compared urinary excretion ratios of lactulose (L) to mannitol [(M) LMR] after ingestion in liquid formulation (LF) or in delayed-release, methacrylate-coated capsules (CAP). Both formulations were radiolabeled. Urine was collected every 2 hours from 0–8h, and from 8–24h. Two hours after LF, gastric residual was 15.9 ± 6.2 % (SEM), and the percentage in colon was 49.6 ± 7.8 %; in 11/12 participants, liquid had entered colon within 2h. Average CAP arrival time in colon was 5.16 ± 0.46h (mode 6 h). After LF, mannitol was extensively absorbed in the first 8h; lactulose absorption was low thoughout the 24h. After the LF, the LMR (geometric mean, 95% CI/hour) in the 0–2h urine was 0.08 [0.05, 0.11]), which was lower than in 8–24h urine (0.32,[0.16, 0.46]; p<0.05). Urine LMRs at 8–24h were similar after LF or CAP. We concluded that, after LF, sugar excretion in 0–2h urine may reflect both SI and colon permeability. Colonic permeability is reflected by urine sugar excretion between 6 and 24h. CAP delivery reduces mannitol excreted at 0–6h, compared to LF. The 0 to 5 or 6h 2-SE urine likely reflects both SI and colon permeability; the higher LMR in the 8–24h urine relative to 0–2h urine should be interpreted with caution and does not mean that colon is more permeable than SI. |
| Related Links | http://dx.doi.org/10.1111/j.1365-2982.2009.01361.x |
| Starting Page | 15 |
| File Format | |
| ISSN | 13501925 |
| e-ISSN | 13652982 |
| Journal | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher Date | 2009-07-01 |
| Access Restriction | Open |
| Subject Keyword | Gastroenterology Physiology Endocrine and Autonomic Systems Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Endocrine and Autonomic Systems Gastroenterology |
