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| Content Provider | PubMed Central |
|---|---|
| Author | Melanie, Zaparty Esser, Dominik Gertig, Susanne Haferkamp, Patrick Theresa, Kouril Andrea, Manica Pham, Trong K. Reimann, Julia Schreiber, Kerstin Pawel, Sierocinski Teichmann, Daniela Wolferen, Marleen Van Jan, Mathias Von Wieloch, Patricia Albers, Sonja V. Driessen, Arnold J. M. Klenk, Hans-peter Schleper, Christa Schomburg, Dietmar Oost, John Van Der Wright, Phillip C. Siebers, Bettina |
| Abstract | Within the archaea, the thermoacidophilic crenarchaeote Sulfolobus solfataricus has become an important model organism for physiology and biochemistry, comparative and functional genomics, as well as, more recently also for systems biology approaches. Within the Sulfolobus Systems Biology (“SulfoSYS”)-project the effect of changing growth temperatures on a metabolic network is investigated at the systems level by integrating genomic, transcriptomic, proteomic, metabolomic and enzymatic information for production of a silicon cell-model. The network under investigation is the central carbohydrate metabolism. The generation of high-quality quantitative data, which is critical for the investigation of biological systems and the successful integration of the different datasets, derived for example from high-throughput approaches (e.g., transcriptome or proteome analyses), requires the application and compliance of uniform standard protocols, e.g., for growth and handling of the organism as well as the “–omics” approaches. Here, we report on the establishment and implementation of standard operating procedures for the different wet-lab and in silico techniques that are applied within the SulfoSYS-project and that we believe can be useful for future projects on Sulfolobus or (hyper)thermophiles in general. Beside established techniques, it includes new methodologies like strain surveillance, the improved identification of membrane proteins and the application of crenarchaeal metabolomics. |
| Related Links | http://dx.doi.org/10.1007/s00792-009-0280-0 |
| Ending Page | 142 |
| Page Count | 24 |
| Starting Page | 119 |
| File Format | |
| ISSN | 14310651 |
| e-ISSN | 14334909 |
| Journal | Extremophiles |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Springer Japan |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Rights Holder | Springer Japan |
| Subject Keyword | Molecular Medicine Microbiology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Medicine Microbiology |
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