NDLI: Flow Interface for Charge Reduced Electrospray of Nanoparticle Solutions

Content Provider	PubMed Central
Author	Adou, Kouame Johnston, Murray V.
Abstract	A charge reduction (CR) interface for electrospray ionization was characterized that permits simultaneous analysis of nanoparticle solutions by multiple detection methods. In the direct infusion configuration, a constant flow of analyte solution undergoes electrospray ionization (ESI). The charged aerosol is sampled directly into the atmospheric pressure inlet of a quadrupole time-of-flight mass spectrometer (QTOF) and to a CR device followed by a differential mobility analyzer (DMA) and condensation particle counter (CPC). In the plug injection configuration, analyte solution is injected into a liquid chromatograph. The effluent is split to an evaporative light scattering detector (ELSD) and the ESI interface. The charged aerosol is then sampled through the CR device directly into the CPC. Performance characteristics of the two configurations were studied with sucrose and protein solutions. When a liquid flow rate in the low µL/min range was used, the reconstructed droplet size distribution from the ESI interface had an average diameter of 184 nm with a geometric standard deviation of 1.4. For the first configuration, the linear working range was wider for ESI-MS than CR-DMA-CPC. For the second configuration, the detection efficiency, defined as the fraction of molecules flowing through the ESI interface that are ultimately detected by the CPC, was on the order of 10−6. Simultaneous measurements with ELSD and CPC were consistent with analyte molecular size and may provide a means of estimating the size of unknown particles.
Related Links	http://dx.doi.org/10.1021/ac902275h
Ending Page	10192
Page Count	7
Starting Page	10186
File Format	PDF
ISSN	00032700
e-ISSN	15206882
Journal	Analytical chemistry
Issue Number	24
Volume Number	81
Language	English
Publisher Date	2009-12-15
Access Restriction	Open
Subject Keyword	Analytical Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrospray Droplet Exposure to Gaseous Acids for the Manipulation of Protein Charge State Distributions

Negative Electrospray Droplet Exposure to Gaseous Bases for the Manipulation of Protein Charge State Distributions

Rapid, Direct Analysis of Cholesterol by Charge Labeling in Reactive Desorption Electrospray Ionization

Engineering the Nanoparticle-Protein Interface: Applications and Possibilities

3D-Printed Fluidic Devices for Nanoparticle Preparation and Flow-Injection Amperometry Using Integrated Prussian Blue Nanoparticle-Modified Electrodes

Elastomeric Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nano-Flow Regime

Quantitative Multiple Reaction Monitoring of Peptide Abundance Introduced via a Capillary Zone Electrophoresis-Electrospray Interface

Electrospray characteristic curves: in pursuit of improved performance in the nano-flow regime

A Nanoparticle-based Solid Phase Extraction Method for Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometric Analysis

Flow Interface for Charge Reduced Electrospray of Nanoparticle Solutions

Similar Documents

Electrospray Droplet Exposure to Gaseous Acids for the Manipulation of Protein Charge State Distributions

Negative Electrospray Droplet Exposure to Gaseous Bases for the Manipulation of Protein Charge State Distributions

Rapid, Direct Analysis of Cholesterol by Charge Labeling in Reactive Desorption Electrospray Ionization

Engineering the Nanoparticle-Protein Interface: Applications and Possibilities

3D-Printed Fluidic Devices for Nanoparticle Preparation and Flow-Injection Amperometry Using Integrated Prussian Blue Nanoparticle-Modified Electrodes

Elastomeric Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nano-Flow Regime

Quantitative Multiple Reaction Monitoring of Peptide Abundance Introduced via a Capillary Zone Electrophoresis-Electrospray Interface

Electrospray characteristic curves: in pursuit of improved performance in the nano-flow regime

A Nanoparticle-based Solid Phase Extraction Method for Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometric Analysis

Flow Interface for Charge Reduced Electrospray of Nanoparticle Solutions