NDLI: Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population

Content Provider	PubMed Central
Author	Zhang, Yanxu Tao, Shu Shen, Huizhong Ma, Jianmin
Abstract	An Euler atmospheric transport model (Canadian Model for Environmental Transport of Organochlorine Pesticides, CanMETOP) was applied and validated to estimate polycyclic aromatic hydrocarbon (PAH) ambient air concentrations at ground level in China based on a high-resolution emission inventory. The results were used to evaluate lung cancer risk for the Chinese population caused by inhalation exposure to PAHs. The uncertainties of the transport model, exposure, and risk analysis were assessed by using Monte Carlo simulation, taking into consideration the variation in PAH emission, aerosol and OH radical concentrations, dry deposition, respiration rate, and genetic susceptibility. The average benzo[a]pyrene equivalent concentration (B[a]Peq) was 2.43 [≈1.29–4.50 as interquartile range (IR)] ng/m3. The population-weighted B[a]Peq was 7.64 (IR, ≈4.05–14.1) ng/m3 because of the spatial overlap of the emissions and population density. It was estimated that 5.8% (IR, ≈2.0–11%) of China's land area, where 30% (IR, ≈17–43%) of the population lives, exceeded the national ambient B[a]Peq standard of 10 ng/m3. Taking into consideration the variation in exposure concentration, respiration rate, and susceptibility, the overall population attributable fraction (PAF) for lung cancer caused by inhalation exposure to PAHs was 1.6% (IR, ≈0.91–2.6%), corresponding to an excess annual lung cancer incidence rate of 0.65 × 10−5. Although the spatial variability was high, the lung cancer risk in eastern China was higher than in western China, and populations in major cities had a higher risk of lung cancer than rural areas. An extremely high PAF of >44% was estimated in isolated locations near small-scale coke oven operations.
Related Links	http://dx.doi.org/10.1073/pnas.0905756106
Ending Page	21067
Page Count	5
Starting Page	21063
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	50
Volume Number	106
Language	English
Publisher	National Academy of Sciences
Publisher Date	2009-12-15
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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