NDLI: Naphthoquinones and Bioactive Compounds from Tobacco as Modulators of Neuronal Nitric Oxide Synthase Activity

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Naphthoquinones and Bioactive Compounds from Tobacco as Modulators of Neuronal Nitric Oxide Synthase Activity

Content Provider	PubMed Central
Author	Priya, Venkatakrishnan Gary, Gairola C. Castagnoli, Neal Miller, R. Timothy
Abstract	Studies were conducted with extracts of several varieties of tobacco in search of neuronal nitric oxide synthase (nNOS) inhibitors which may be of value in the treatment of stroke. Current therapies do not directly exploit modulation of nNOS activity due to poor selectivity of the currently available nNOS inhibitors. The properties of a potentially novel nNOS inhibitor(s) derived from tobacco extracts, and the concentration-dependent, modulatory effects of the tobacco-derived naphthoquinone compound, 2, 3, 6-trimethyl-1, 4-naphthoquinone (TMN), on nNOS activity were investigated, using 2-methyl-1, 4-naphthoquinone (menadione) as a control. Up to 31μM, both TMN and menadione stimulated nNOS-catalyzed L-citrulline production. However, at higher concentrations of TMN (62.5-500 μM), the stimulation was lost in a concentration-dependent manner. With TMN, the loss of stimulation did not decrease beyond the control activity. With menadione (62.5-500 μM), the loss of stimulation surpassed that of the control (78 ± 0.01%), indicating a complete inhibition of nNOS activity. This study suggests that potential nNOS inhibitors are present in tobacco, most of which remain to be identified.
Related Links	http://dx.doi.org/10.1002/ptr.2789
Ending Page	1672
Page Count	10
Starting Page	1663
File Format	PDF
ISSN	0951418X
e-ISSN	10991573
Journal	Phytotherapy research : PTR
Issue Number	12
Volume Number	23
Language	English
Publisher Date	2009-12-01
Access Restriction	Open
Subject Keyword	Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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