NDLI: Stem-like ovarian cancer cells can serve as tumor vascular progenitors

Please wait, while we are loading the content...

Doublecortin and CaM Kinase-like-1 and Leucine-Rich-Repeat-Containing G-Protein-Coupled Receptor Mark Quiescent and Cycling Intestinal Stem Cells, Respectively

Nodal Signaling via an Autocrine Pathway Promotes Proliferation of Mouse Spermatogonial Stem/Progenitor Cells through Smad2/3 and Oct-4 Activation

Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments using In Vivo Bioluminescence Imaging

Year: 2009, Volume: 27, Issue: 9

Year: 2009, Volume: 27, Issue: 8

Year: 2009, Volume: 27, Issue: 7

Year: 2009, Volume: 27, Issue: 6

Year: 2009, Volume: 27, Issue: 5

Year: 2009, Volume: 27, Issue: 4

Year: 2009, Volume: 27, Issue: 3

Year: 2009, Volume: 27, Issue: 2

Year: 2009, Volume: 27, Issue: 1

Year: 2008, Volume: 26

Year: 2007, Volume: 25

Year: 2006, Volume: 24

Year: 2005, Volume: 23

Year: 2004, Volume: 22

Year: 2002, Volume: 20

Year: 1997, Volume: 15

Year: 1995, Volume: 13

Stem-like ovarian cancer cells can serve as tumor vascular progenitors

Content Provider	PubMed Central
Author	Alvero, Ayesha B. Fu, Han-hsuan Holmberg, Jennie Visintin, Irene Mor, Liora Marquina, Carlos Cano Jessica, Oidtman Silasi, Dan-arin Mor, Gil
Abstract	Neovascularization is required for solid tumor maintenance, progression, and metastasis. The most described contribution of cancer cells in tumor neovascularization is the secretion of factors, which attract various cell types to establish a microenvironment that promote blood vessel formation. The cancer stem cell hypothesis suggests that tumors are composed of cells that may share the differentiation capacity of normal stem cells. Similar to normal stem cells, cancer stem cells (CSCs) have the capacity to acquire different phenotypes. Thus, it is possible that CSCs have a bigger role in the process of tumor neovascularization. In this study, we show the capacity of a specific population of ovarian cancer cells with stem-like properties to give rise to xenograft tumors containing blood vessels, which are lined by human CD34+ cells. In addition, when cultured in high-density Matrigel, these cells mimic the behavior of normal endothelial cells and can form vessel-like structures in 24h. Microscopic analysis showed extensive branching and maturation of vessel-like structures in 7 days. Western blot and flow cytometry analysis showed that this process is accompanied by the acquisition of classical endothelial markers, CD34 and VE-cadherin. More importantly, we show that this process is VEGF-independent, but IKKβ-dependent. Our findings suggest that anti-angiogenic therapies should take into consideration the inherent capacity of these cells to serve as vascular progenitors.
Related Links	http://dx.doi.org/10.1002/stem.191
Ending Page	2413
Page Count	9
Starting Page	2405
File Format	PDF
ISSN	10665099
e-ISSN	15494918
Journal	Stem cells (Dayton, Ohio)
Issue Number	10
Volume Number	27
Language	English
Publisher Date	2009-10-01
Access Restriction	Open
Subject Keyword	Developmental Biology Molecular Medicine Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Stem-like ovarian cancer cells can serve as tumor vascular progenitors.

Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

Endothelial Progenitors as Tools to Study Vascular Disease

Concise Review: Vascular Stem Cells and Tumor Angiogenesis

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells.

Porcine Skin-Derived Stem Cells Can Serve as Donor Cells for Nuclear Transfer

Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells

TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence

Stem-like ovarian cancer cells can serve as tumor vascular progenitors

Similar Documents

Stem-like ovarian cancer cells can serve as tumor vascular progenitors.

Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

Endothelial Progenitors as Tools to Study Vascular Disease

Concise Review: Vascular Stem Cells and Tumor Angiogenesis

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells.

Porcine Skin-Derived Stem Cells Can Serve as Donor Cells for Nuclear Transfer

Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells

TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence

Stem-like ovarian cancer cells can serve as tumor vascular progenitors