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| Content Provider | PubMed Central |
|---|---|
| Author | Anderson, Alexander Ra Hassanein, Mohamed Branch, Kevin M. Lu, Jenny Lobdell, Nichole A. Maier, Julie Basanta, David Brandy, Weidow Archana, Narasanna Arteaga, Carlos L. Reynolds, Albert B. Quaranta, Vito Estrada, Lourdes Weaver, Alissa M. |
| Abstract | Tumor-microenvironment interactions are increasingly recognized to influence tumor progression. To understand the competitive dynamics of tumor cells in diverse microenvironments, we experimentally parameterized a hybrid discrete-continuum mathematical model with phenotypic trait data from a set of related mammary cell lines with normal, transformed, or tumorigenic properties. Surprisingly, in a resource-rich microenvironment, with few limitations on proliferation or migration, transformed but not tumorigenic cells were most successful and outcompeted other cell types in heterogeneous tumor simulations. Conversely, constrained microenvironments with limitations on space and/or growth factors gave a selective advantage to phenotypes derived from tumorigenic cell lines. Analysis of the relative performance of each phenotype in constrained versus unconstrained microenvironments revealed that, although all cell types grew more slowly in resource-constrained microenvironments, the most aggressive cells were least affected by microenvironmental constraints. A game theory model testing the relationship between microenvironment resource availability and competitive cellular dynamics supports the concept that microenvironmental independence is an advantageous cellular trait in resource-limited microenvironments. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.CAN-09-0437 |
| Starting Page | 8797 |
| File Format | |
| ISSN | 15387445 |
| e-ISSN | 15387445 |
| Journal | Cancer research |
| Issue Number | 22 |
| Volume Number | 69 |
| Language | English |
| Publisher Date | 2009-11-15 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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