NDLI: Nitric Oxide Production by the Human Intestinal Microbiota by Dissimilatory Nitrate Reduction to Ammonium

Content Provider	PubMed Central
Author	Vermeiren, Joan Wiele, Tom Van De Verstraete, Willy Boeckx, Pascal Boon, Nico
Copyright Year	2009
Abstract	The free radical nitric oxide (NO) is an important signaling molecule in the gastrointestinal tract. Besides eukaryotic cells, gut microorganisms are also capable of producing NO. However, the exact mechanism of NO production by the gut microorganisms is unknown. Microbial NO production was examined under in vitro conditions simulating the gastrointestinal ecosystem using L-arginine or nitrate as substrates. L-arginine did not influence the microbial NO production. However, NO concentrations in the order of 90 ng NO-N per L feed medium were produced by the fecal microbiota from nitrate. 15N tracer experiments showed that nitrate was mainly reduced to ammonium by the dissimilatory nitrate reduction to ammonium (DNRA) pathway. To our knowledge, this is the first study showing that gastrointestinal microbiota can generate substantial amounts of NO by DNRA and not by the generally accepted denitrification or L-arginine pathway. Further work is needed to elucidate the exact role between NO produced by the gastrointestinal microbiota and host cells.
Related Links	http://dx.doi.org/10.1155/2009/284718
Starting Page	284718
File Format	PDF
ISSN	11107243
e-ISSN	11107251
Journal	Journal of Biomedicine and Biotechnology
Volume Number	2009
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2009-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Biotechnology Molecular Medicine Genetics Health, Toxicology and Mutagenesis Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Health, Toxicology and Mutagenesis Molecular Biology Molecular Medicine Biotechnology

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