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| Content Provider | PubMed Central |
|---|---|
| Author | Zheng, Duo Cho, Yong-yeon Lau, Andy T. Y. Zhang, Jishuai Ma, Wei-ya Bode, Ann M. Dong, Zigang |
| Abstract | Cyclin-dependent kinase (cdk) 3, a member of the cdk family of kinases, plays a critical role in cell cycle regulation and is involved in G0-G1 and G1-S cell cycle transitions. However, the role of cdk3 in cell proliferation, as well as cell transformation, is not yet clearly understood. Here, we report that the protein expression level of cdk3 is higher in human cancer cell lines and human glioblastoma tissue compared with normal brain tissue. Furthermore, we found that cdk3 phosphorylates ATF1 at serine 63 and enhances transactivation and transcriptional activity of ATF1. Results also indicated that siRNA directed against cdk3 (si-cdk3) suppresses ATF1 activity, resulting in inhibition of cell proliferation and growth of human glioblastoma T98G cells in soft agar. Importantly, we showed that cdk3 enhances EGF-induced transformation of JB6 Cl41 cells and si-cdk3 suppresses RasG12V/cdk3/ATF1-induced foci formation in NIH3T3 cells. These results clearly demonstrated that the cdk3-ATF1 signaling axis is critical for cell proliferation and transformation. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.can-08-1137 |
| Ending Page | 7660 |
| Page Count | 11 |
| Starting Page | 7650 |
| File Format | |
| ISSN | 00085472 |
| e-ISSN | 15387445 |
| Journal | Cancer research |
| Issue Number | 18 |
| Volume Number | 68 |
| Language | English |
| Publisher Date | 2008-09-15 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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