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| Content Provider | PubMed Central |
|---|---|
| Author | Ramasamy, Jagadeeswaran Hanna, Surawska Krishnaswamy, Soundararajan Varalakshmi, Janamanchi Mackinnon, A. Craig Seiwert, Tanguy Y. Loganathan, Sivakumar Rajani, Kanteti Reichman, Trevor Vidya, Nallasura Schwartz, Stuart Faoro, Leonardo Wang, Yi-ching Girard, Luc Tretiakova, Maria S. Ahmed, Salman Zumba, Osvaldo Soulii, Lioubov Bindokas, Vytas P. Szeto, Livia L. Gordon, Gavin J. Bueno, Raphael David, Sugarbaker Lingen, Mark W. Sattler, Martin Krausz, Thomas Vigneswaran, Wickii Natarajan, Viswanathan Minna, John Vokes, Everett E. Ferguson, Mark K. Husain, Aliya N. Ravi, Salgia |
| Abstract | Lung cancer is characterized by abnormal cell growth and invasion, and the actin cytoskeleton plays a major role in these processes. The focal adhesion protein paxillin is a target of a number of oncogenes involved in key signal transduction and important in cell motility and migration. In lung cancer tissues, we have found that paxillin was highly expressed (compared with normal lung), amplified (12.1%, 8 of 66) and correlated with increased MET and epidermal growth factor receptor (EGFR) gene copy numbers, or mutated (somatic mutation rate of 9.4%, 18 of 191). Paxillin mutations (19 of 21) were clustered between LD motifs 1 and 2 and the LIM domains. The most frequent point mutation (A127T) enhanced lung cancer cell growth, colony formation, focal adhesion formation, and colocalized with Bcl-2 in vitro. Gene silencing from RNA interference of mutant paxillin led to reduction of cell viability. A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. These results establish an important role for paxillin in lung cancer. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.can-07-1998 |
| Ending Page | 142 |
| Page Count | 11 |
| Starting Page | 132 |
| File Format | |
| ISSN | 00085472 |
| e-ISSN | 15387445 |
| Journal | Cancer research |
| Issue Number | 1 |
| Volume Number | 68 |
| Language | English |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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