NDLI: Scents and Nonsense: Olfactory Dysfunction in Schizophrenia

Content Provider	PubMed Central
Author	Turetsky, Bruce I. Hahn, Chang-gyu Karin, Borgmann-winter Moberg, Paul J.
Copyright Year	2009
Abstract	Among the sensory modalities, olfaction is most closely associated with the frontal and temporal brain regions that are implicated in schizophrenia and most intimately related to the affective and mnemonic functions that these regions subserve. Olfactory probes may therefore be ideal tools through which to assess the structural and functional integrity of the neural substrates that underlie disease-related cognitive and emotional disturbances. Perhaps more importantly, to the extent that early sensory afferents are also disrupted in schizophrenia, the olfactory system—owing to its strategic anatomic location—may be especially vulnerable to such disruption. Olfactory dysfunction may therefore be a sensitive indicator of schizophrenia pathology and may even serve as an “early warning” sign of disease vulnerability or onset. In this article, we review the evidence supporting a primary olfactory sensory disturbance in schizophrenia. Convergent data indicate that structural and functional abnormalities extend from the cortex to the most peripheral elements of the olfactory system. These reflect, in part, a genetically mediated neurodevelopmental etiology. Gross structural and functional anomalies are mirrored by cellular and molecular abnormalities that suggest decreased or faulty innervation and/or dysregulation of intracellular signaling. A unifying mechanistic hypothesis may be the epigenetic regulation of gene expression. With the opportunity to obtain olfactory neural tissue from live patients through nasal epithelial biopsy, the peripheral olfactory system offers a uniquely accessible window through which the pathophysiological antecedents and sequelae of schizophrenia may be observed. This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers.
Related Links	http://dx.doi.org/10.1093/schbul/sbp111
Ending Page	1131
Page Count	15
Starting Page	1117
File Format	PDF
ISSN	05867614
e-ISSN	17451701
Journal	Schizophrenia Bulletin
Issue Number	6
Volume Number	35
Language	English
Publisher	Oxford University Press
Publisher Date	2009-11-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Scents and nonsense: olfactory dysfunction in schizophrenia.

Olfactory Processing, Sex Effects and Heterogeneity in Schizophrenia

Olfactory Hedonic Judgment in Patients With Deficit Syndrome Schizophrenia

Olfactory dysfunction in Alzheimer’s disease

Insight Into Neurocognitive Dysfunction in Schizophrenia

Olfactory identification in young relatives at risk for schizophrenia

Dopaminergic Dysfunction in Schizophrenia: Salience Attribution Revisited

Olfactory Physiological Impairment in First-Degree Relatives of Schizophrenia Patients

PROTEOGLYCAN ABNORMALITIES IN OLFACTORY EPITHELIUM TISSUE FROM SUBJECTS DIAGNOSED WITH SCHIZOPHRENIA

Scents and Nonsense: Olfactory Dysfunction in Schizophrenia

Similar Documents

Scents and nonsense: olfactory dysfunction in schizophrenia.

Olfactory Processing, Sex Effects and Heterogeneity in Schizophrenia

Olfactory Hedonic Judgment in Patients With Deficit Syndrome Schizophrenia

Olfactory dysfunction in Alzheimer’s disease

Insight Into Neurocognitive Dysfunction in Schizophrenia

Olfactory identification in young relatives at risk for schizophrenia

Dopaminergic Dysfunction in Schizophrenia: Salience Attribution Revisited

Olfactory Physiological Impairment in First-Degree Relatives of Schizophrenia Patients

PROTEOGLYCAN ABNORMALITIES IN OLFACTORY EPITHELIUM TISSUE FROM SUBJECTS DIAGNOSED WITH SCHIZOPHRENIA

Scents and Nonsense: Olfactory Dysfunction in Schizophrenia