NDLI: Safety and efficacy of telbivudine for the treatment of chronic hepatitis B

Please wait, while we are loading the content...

Year: 2016, Volume: 12

Year: 2015, Volume: 12

Year: 2015, Volume: 11

Year: 2014, Volume: 11

Year: 2014, Volume: 10

Year: 2013, Volume: 10

Year: 2013, Volume: 9

Year: 2012, Volume: 9

Year: 2012, Volume: 8

Year: 2011, Volume: 7

Year: 2010, Volume: 6

Year: 2009, Volume: 5

Year: 2009, Volume: 5, Issue: Unspecified

Minimizing cardiac surgery risks in a Hepatitis C patient: Changing surgical strategy after evaluation by modern imaging technologies

Nd: YAG capsulotomy for posterior capsule opacification after combined clear corneal phacoemulsification and vitrectomy

Current trends in the treatment of polycystic ovary syndrome with desire for children

Role of rasagiline in treating Parkinson’s disease: Effect on disease progression

Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency

Incidence and causes of neonatal hyperbilirubinemia in a center of Catania

Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide

Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability

Regimen complexity and medication nonadherence in elderly patients

Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis

Regular use of traditional analgesics predicts major coronary events: A cohort study

Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection

Current trends in the treatment of hepatic encephalopathy

Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis

Role of atazanavir in the treatment of HIV infection

An evidence-based review of natalizumab therapy in the management of Crohn’s disease

Epileptic seizure after treatment with thiocolchicoside

Pegylated liposomal doxorubicin in ovarian cancer

Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety

Tenofovir and its potential in the treatment of hepatitis B virus

Casopitant: a novel NK1-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting

Fesoterodine for the treatment of urinary incontinence and overactive bladder

Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update

Challenging issues in molecular-targeted therapy

Pemetrexed as first-line therapy for non-squamous non-small cell lung cancer

Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir

The role of rifaximin in the treatment and chemoprophylaxis of travelers’ diarrhea

Treatment of osteoporosis with annual iv zoledronic acid: effects on hip fracture

A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers

EUS-guided transmural drainage for peripancreatic fluid collections using fine needle and stiff fine guidewire without electrocautery: An optional safe technique

Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women

Severe hypotony and filtering bleb leak after intravitreal injection of ranibizumab

Effectiveness and side effects of anti-CD20 therapy for autoantibody-mediated blistering skin diseases: A comprehensive survey of 71 consecutive patients from the Initial use to 2007

A controlled, randomized nonblinded clinical trial to assess the efficacy of amphotericin B deoxycholate as compared to pentamidine for the treatment of antimony unresponsive visceral leishmaniasis cases in Bihar, India

The benefits and risks of testosterone replacement therapy: a review

Dyslipidemia in Iranian overweight and obese children

Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol

Guidelines for the treatment of bacterial vaginosis: focus on tinidazole

Management of glucocorticoids-induced osteoporosis: role of teriparatide

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

Natalizumab in the treatment of multiple sclerosis

Treatment of recurrent epithelial ovarian cancer

Mycophenolic acid formulations in adult renal transplantation – update on efficacy and tolerability

Managing pediatric hepatitis C: current and emerging treatment options

Animal-derived surfactants for the treatment and prevention of neonatal respiratory distress syndrome: summary of clinical trials

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain

Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma

In-hospital resuscitation: opioids and other factors influencing survival

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Intraperitoneal chemotherapy in the management of ovarian cancer: focus on carboplatin

Update on the management of attention-deficit/hyperactivity disorder in children and adults: patient considerations and the role of lisdexamfetamine

Update on the use of deferasirox in the management of iron overload

Pediatric psoriasis: an update

Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review

Anthracycline extravasation injuries: management with dexrazoxane

Life-threatening hemorrhage following subcutaneous heparin therapy

Long-term efficacy and safety of letrozole for the adjuvant treatment of early breast cancer in postmenopausal women: a review

Comparison of linear–stochastic and nonlinear–deterministic algorithms in the analysis of 15-minute clinical ECGs to predict risk of arrhythmic death

Angioid streaks, clinical course, complications, and current therapeutic management

Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations

Antimalarials and the fight against malaria in Brazil

Alglucosidase alfa: Long term use in the treatment of patients with Pompe disease

Treatment and chemoprevention of NSAID-associated gastrointestinal complications

Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures

Incretin-based therapies: new treatments for type 2 diabetes in the new millennium

Management strategies for pulmonary sarcoidosis

Safety and efficacy of telbivudine for the treatment of chronic hepatitis B

Management of postoperative nausea and vomiting: focus on palonosetron

Does nonadherence to local recommendations for empirical antibiotic therapy on admission to the intensive care unit have an impact on in-hospital mortality?

Substitution of anticonvulsant drugs

New therapies in the management of Niemann-Pick type C disease: clinical utility of miglustat

Role of everolimus in the treatment of renal cell carcinoma

Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review

Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection

Finasteride in the treatment of patients with benign prostatic hyperplasia: a review

Pharmacotherapy of pediatric and adolescent HIV infection

Recombinant factor VIII in the management of hemophilia A: current use and future promise

Artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria

Topical retapamulin in the management of infected traumatic skin lesions

The pathophysiology of paroxysmal nocturnal hemoglobinuria and treatment with eculizumab

Recombinant human epoetin beta in the treatment of chemotherapy-related anemia

Cecal perforation with an ascending colon cancer caused by upper gastrointestinal endoscopy

Celecoxib in arthritis: relative risk management profile and implications for patients

A new extended release formulation (OROS ® ) of hydromorphone in the management of pain

Once-daily medications for the pharmacological management of ADHD in adults

Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem

Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis

Fludarabine in the treatment of chronic lymphocytic leukemia: a review

The role of urate and xanthine oxidase in vascular oxidative stress: future directions

Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses

Voiding cystourethrogram in the diagnosis of vesicoureteric reflux in children with antenatally diagnosed hydronephrosis

Luteal Phase Support in assisted reproductive technology treatment: focus on Endometrin® (progesterone) vaginal insert

Role of oxaliplatin in the treatment of colorectal cancer

Fatty liver in children

A review of the use of exemestane in early breast cancer

Dasatinib in chronic myeloid leukemia: a review

Managing Behçet’s disease: An update on current and emerging treatment options

Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist

Associations of anemia persistency with medical expenditures in Medicare ESRD patients on dialysis

Year: 2008, Volume: 4

Year: 2007, Volume: 3

Year: 2006, Volume: 2

Year: 2005, Volume: 1

Safety and efficacy of telbivudine for the treatment of chronic hepatitis B

Content Provider	PubMed Central
Author	Osborn, Melissa K.
Abstract	Telbivudine was recently approved for the treatment of chronic hepatitis B. Phase III studies indicated its antiviral potency with 6- to 6.5-log copies/mL reductions in hepatitis B DNA levels at year 1, comparable to other potent agents such as entecavir or tenofovir. Genotypic resistance rates, however, reached 25% at year 2 in hepatitis B e-antigen positive subjects and 11% in hepatitis B e-antigen negative subjects, preventing it from becoming a preferred first-line drug for hepatitis B. Furthermore, its signature resistance mutation (a change from methionine to isoleucine at position 204 in the reverse transcriptase domain of the hepatitis B polymerase) also confers cross-resistance to entecavir, lamivudine, and emtricitabine. Telbivudine is well tolerated, with elevations in creatine phosphokinase being the most common abnormality observed in clinical trials. Most often, elevations were asymptomatic. Future research in hepatitis B will focus on the best ways to use existing therapies, including telbivudine, sequentially or in combination in order to maximize viral suppression and minimize the development of antiviral resistance.
Ending Page	798
Starting Page	789
File Format	PDF
ISSN	1178203X
e-ISSN	1178203X
Journal	Therapeutics and Clinical Risk Management
Volume Number	5
Language	English
Publisher	Dove Medical Press
Publisher Date	2009-01-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Safety Research Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) Chemical Health and Safety

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in