NDLI: The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction

Content Provider	PubMed Central
Author	Ishida, Satoru Yamane, Shoji Nakano, Saori Yanagimoto, Toru Hanamoto, Yukie Miki, Maeda-tanimura Toyosaki-maeda, Tomoko Ishizaki, Jun Matsuo, Yoshiyuki Fukui, Naoshi Itoh, Tsunetoshi Ochi, Takahiro Suzuki, Ryuji
Copyright Year	2009
Abstract	Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) of CD14+ monocytes cocultured with nurse-like cells isolated from RA synovium, but not of freshly isolated CD14+ monocytes. Receptor activator of nuclear factor-κB ligand (RANKL) enhanced this LIGHT-induced generation of TRAP-positive MNCs. The MNCs showed the phenotypical and functional characteristics of osteoclasts; they showed the expression of osteoclast markers such as cathepsin K, actin-ring formation, and the ability to resorb bone. Moreover, the MNCs expressed both matrix metalloproteinase 9 (MMP-9) and MMP-12, but the latter was not expressed in osteoclasts induced from CD14+ monocytes by RANKL. Immunohistochemical analysis showed that the MMP-12-producing MNCs were present in the erosive areas of joints in RA, but not in the affected joints of osteoarthritic patients. These findings suggested that LIGHT might be involved in the progression of inflammatory bone destruction in RA, and that osteoclast progenitors might become competent for LIGHT-mediated osteoclastogenesis via interactions with synoviocyte-like nurse-like cells.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2008.02965.x
Starting Page	315
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	1 Pt 2
Volume Number	128
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2009-09-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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