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| Content Provider | PubMed Central |
|---|---|
| Author | Erdmann, Kati Grosser, Nina Schröder, Henning |
| Abstract | The amino acid L-methionine is known to exert antioxidant effects by as yet unidentified mechanisms. In the present study, L-methionine led to a concentration-dependent induction of the antioxidant protein heme oxygenase-1 (HO-1) and ferritin in cultured endothelial cells (ECV 304). HO-1 protein expression was accompanied by an increased catalytic activity of the enzyme. Long-term pre-incubation of endothelial cells with L-methionine reduced NADPH-mediated radical formation by up to 60%. The antioxidant effect of L-methionine was mimicked by the HO-1 product bilirubin, which suppressed free radical formation and almost completely. Reduction of superoxide generation by L-methionine was inhibited in the presence of the nitric oxide (NO) synthase inhibitor L-NMMA, suggesting the involvement of endogenous NO in L-methionine-dependent cytoprotection. These findings demonstrate that L-methionine reduces free radical formation in endothelial cells, possibly through induction of heme oxygenase-1 and ferritin. This novel, indirect antioxidant action might be relevant for the preventive potential of methionine and methionine rich diets under conditions of inflammation and oxidative stress. |
| Related Links | http://dx.doi.org/10.1208/aapsj070118 |
| Ending Page | 200 |
| Starting Page | 195 |
| File Format | |
| ISSN | 15507416 |
| e-ISSN | 15507416 |
| Journal | The AAPS Journal |
| Issue Number | 1 |
| Volume Number | 7 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2005-08-29 |
| Access Restriction | Open |
| Rights Holder | Springer-Verlag |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
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