NDLI: Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

Content Provider	PubMed Central
Author	Cronin, Wendy A. Golub, Jonathan E. Lathan, Monica J. Mukasa, Leonard N. Hooper, Nancy Razeq, Jafar H. Baruch, Nancy G. Mulcahy, Donna Benjamin, William H. Magder, Laurence S. Strickland, G. Thomas Bishai, William R.
Abstract	To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1,172 (99%) of 1,179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 114 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that eliminating diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.
Related Links	http://dx.doi.org/10.3201/eid0811.020261
Ending Page	1279
Page Count	9
Starting Page	1271
File Format	PDF
ISSN	10806040
e-ISSN	10806059
Journal	Emerging Infectious Diseases
Issue Number	11
Volume Number	8
Language	English
Publisher	Centers for Disease Control and Prevention
Publisher Date	2002-11-01
Access Restriction	Open
Rights Holder	Centers for Disease Control and Prevention
Subject Keyword	Microbiology (medical) Epidemiology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Epidemiology Microbiology (medical)

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