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Shared Neurocognitive Dysfunctions in Young Offspring at Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families

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Shared Neurocognitive Dysfunctions in Young Offspring at Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families

Content Provider	PubMed Central
Author	Michel, Maziade Rouleau, Nancie Gingras, Nathalie Boutin, Pierrette Paradis, Marie-eve Jomphe, Valérie Boutin, Julie Létourneau, Karine Gilbert, Elsa Lefebvre, Andrée-anne Doré, Marie-claire Marino, Cecilia Battaglia, Marco Chantal, Mérette Roy, Marc-andré
Copyright Year	2009
Abstract	Background: Adult patients having schizophrenia (SZ) or bipolar disorder (BP) may have in common neurocognitive deficits. Former evidence suggests impairments in several neuropsychological functions in young offspring at genetic risk for SZ or BP. Moreover, a dose-response relation may exist between the degree of familial loading and cognitive impairments. This study examines the cognitive functioning of high-risk (HR) offspring of parents having schizophrenia (HRSZ) and high-risk offspring of parents having bipolar disorder (HRBP) descending from densely affected kindreds. Methods: The sample consisted of 45 young offspring (mean age of 17.3 years) born to a parent having SZ or BP descending from large multigenerational families of Eastern Québec that are densely affected by SZ or BP and followed up since 1989. The offspring were administered a lifetime best-estimate diagnostic procedure (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [DSM-IV]) and an extensive standard neuropsychological battery. Raw scores were compared with age- and gender-matched controls. Results: The offspring displayed differences in memory and executive functions when compared with controls. Moderate to large effect sizes (Cohen d) ranging from 0.65 to 1.25 (for IQ and memory) were observed. Several of the cognitive dysfunctions were present in both HRSZ and HRBP, even when considering DSM-IV clinical status. Conclusions: HRSZ and HRBP shared several aspects of their cognitive impairment. Our data suggest that the extremely high genetic and familial loading of these HRs may have contributed to a quantitatively increased magnitude of the cognitive impairments in both HR subgroups, especially in memory. These offspring at heightened risk present difficulties in processing information that warrant preventive research.
Related Links	http://dx.doi.org/10.1093/schbul/sbn058
Ending Page	930
Page Count	12
Starting Page	919
File Format	PDF
ISSN	05867614
e-ISSN	17451701
Journal	Schizophrenia Bulletin
Issue Number	5
Volume Number	35
Language	English
Publisher	Oxford University Press
Publisher Date	2009-09-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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Shared Neurocognitive Dysfunctions in Young Offspring at Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families