NDLI: Mechanisms of heme iron absorption: Current questions and controversies

Content Provider	PubMed Central
Author	West, Adrian R. Oates, Phillip S.
Copyright Year	2008
Abstract	Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.
Related Links	http://dx.doi.org/10.3748/wjg.14.4101
Starting Page	4101
File Format	PDF
ISSN	10079327
Journal	World Journal of Gastroenterology : WJG
Issue Number	26
Volume Number	14
Language	English
Publisher	The WJG Press and Baishideng
Publisher Date	2008-01-01
Access Restriction	Open
Rights Holder	The WJG Press and Baishideng
Subject Keyword	Gastroenterology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

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Mechanisms of heme iron absorption: Current questions and controversies