NDLI: The Bone Morphogenetic Protein 1/Tolloid-like Metalloproteinases

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The Bone Morphogenetic Protein 1/Tolloid-like Metalloproteinases

Content Provider	PubMed Central
Author	Hopkins, Delana R. Keles, Sunduz Greenspan, Daniel S.
Abstract	A decade ago, bone morphogenetic protein 1 (BMP1) was shown to provide the activity necessary for proteolytic removal of the C-propeptides of procollagens I–III: precursors of the major fibrillar collagens. Subsequent studies have shown BMP1 to be the prototype of a small group of extracellular metalloproteinases that play manifold roles in regulating formation of the extracellular matrix (ECM). Soon after initial cloning of BMP1, genetic studies showed the related Drosophila proteinase Tolloid (TLD) to be necessary for formation of the dorsal-ventral axis in early embryogenesis. It is now clear that the BMP1/TLD-like proteinases, conserved in species ranging from Drosophila to humans, act in dorsal-ventral patterning via activation of transforming growth factor β (TGFβ)-like proteins BMP2, BMP4 (vertebrates) and decapentaplegic (arthropods). More recently, it has become apparent that the BMP1/TLD-like proteinases are key activators of a broader subset of the TGFβ superfamily of proteins, with implications that these proteinases may be key in orchestrating formation of ECM with growth factor activation and BMP signaling in morphogenetic processes.
Related Links	http://dx.doi.org/10.1016/j.matbio.2007.05.004
Ending Page	523
Page Count	16
Starting Page	508
File Format	PDF
ISSN	0945053X
e-ISSN	15691802
Journal	Matrix biology : journal of the International Society for Matrix Biology
Issue Number	7
Volume Number	26
Language	English
Publisher Date	2007-09-01
Access Restriction	Open
Subject Keyword	Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology

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Sizzled Is Unique among Secreted Frizzled-related Proteins for Its Ability to Specifically Inhibit Bone Morphogenetic Protein-1 (BMP-1)/Tolloid-like Proteinases*

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The Bone Morphogenetic Protein 1/Tolloid-like Metalloproteinases

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