NDLI: Acoustically driven programmable liquid motion using resonance cavities

Content Provider	PubMed Central
Author	Langelier, Sean M. Chang, Dustin S. Zeitoun, Ramsey I. Burns, Mark A.
Abstract	Performance and utility of microfluidic systems are often overshadowed by the difficulties and costs associated with operation and control. As a step toward the development of a more efficient platform for microfluidic control, we present a distributed pressure generation scheme whereby independently tunable pressure sources can be simultaneously controlled by using a single acoustic source. We demonstrate how this scheme can be used to perform precise droplet positioning as well as merging, splitting, and sorting within open microfluidic networks. We further show how this scheme can be implemented for control of continuous-flow systems, specifically for generation of acoustically tunable liquid gradients. Device operation hinges on a resonance-decoding and rectification mechanism by which the frequency content in a composite acoustic input is decomposed into multiple independently buffered output pressures. The device consists of a bank of 4 uniquely tuned resonance cavities (404, 484, 532, and 654 Hz), each being responsible for the actuation of a single droplet, 4 identical flow-rectification structures, and a single acoustic source. Cavities selectively amplify resonant tones in the input signal, resulting in highly elevated local cavity pressures. Fluidic-rectification structures then serve to convert the elevated oscillating cavity pressures into unidirectional flows. The resulting pressure gradients, which are used to manipulate fluids in a microdevice, are tunable over a range of ≈0–200 Pa with a control resolution of 10 Pa.
Related Links	http://dx.doi.org/10.1073/pnas.0900043106
Ending Page	12622
Page Count	6
Starting Page	12617
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	31
Volume Number	106
Language	English
Publisher	National Academy of Sciences
Publisher Date	2009-08-04
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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