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| Content Provider | PubMed Central |
|---|---|
| Author | Choi, Su-mi Lee, Dong-gun Lim, Jihyang Park, Sun Hee Choi, Jung-hyun Yoo, Jin-hong Lee, Jong-wook Kim, Yonggoo Han, Kyungja Min, Woo-sung Shin, Wan-shik Kim, Chun-choo |
| Copyright Year | 2009 |
| Abstract | Successful preemptive therapy for cytomegalovirus (CMV) infection in transplant patients depends on the availability of sensitive, specific, and timely diagnostic tests for CMV infection. Although the pp65 antigenemia assay has been widely used for this purpose, real-time quantification of CMV DNA has recently been recognized as an alternative diagnostic approach. However, the guidelines for antiviral therapy based on real-time quantitative polymerase chain reaction (RQ-PCR) have yet to be established. From November 2004 to March 2005, a total of 555 whole blood samples from 131 hematopoietic stem cell transplant (HSCT) recipients were prospectively collected. RQ-PCR was conducted using an Artus® CMV LC PCR kit (QIAGEN). Both qualitative and quantitative correlations were drawn between the two methods. Exposure to the antiviral agent influenced the results of the two assays. Additionally, the discrepancy was observed at low levels of antigenemia and CMV DNA load. Via ROC curve analysis, the tentative cutoff value for preemptive therapy was determined to be approximately 2×104 copies/mL (sensitivity, 80.0%; specificity, 50.0%) in the high risk patients, and approximately 3×104 copies/mL (sensitivity, 90.0%; specificity, 70.0%) in the patients at low risk for CMV disease. Further study to validate the optimal cutoff value for the initiation of preemptive therapy is currently underway. |
| Related Links | http://dx.doi.org/10.3346/jkms.2009.24.4.571 |
| Starting Page | 571 |
| File Format | |
| ISSN | 10118934 |
| e-ISSN | 15986357 |
| Journal | Journal of Korean Medical Science |
| Issue Number | 4 |
| Volume Number | 24 |
| Language | English |
| Publisher | The Korean Academy of Medical Sciences |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Rights Holder | The Korean Academy of Medical Sciences |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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