NDLI: Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment

Content Provider	PubMed Central
Author	Volkow, Nora D. Tomasi, Dardo Wang, Gene-jack Telang, Frank Fowler, Joanna S. Wang, Ruiliang L. Logan, Jean Wong, Christopher Jayne, Millard Swanson, James M.
Copyright Year	2009
Abstract	Sleep deprivation interferes with cognitive performance but the mechanisms are poorly understood. We recently reported that one night of sleep deprivation increased dopamine in striatum (measured with [11C] raclopride, a PET radiotracer that competes with endogenous dopamine for binding to D2 receptors) and that these increases were associated with impaired performance in a visual attention task. To better understand this association here we evaluate the relationship between changes in striatal dopamine (measured as changes in D2 receptor availability using PET and [11C]raclopride) and changes in brain activation to a visual attention task (measured with BOLD and fMRI) when performed during sleep deprivation versus during rested wakefulness. We find that sleep induced changes in striatal dopamine were associated with changes in cortical brain regions modulated by dopamine (attenuated deactivation of anterior cingulate gyrus and insula) but also in regions that are not recognized targets of dopaminergic modulation (attenuated activation of inferior occipital cortex and cerebellum). Moreover, the increases in striatal dopamine as well as its associated regional activation and deactivation patterns correlated negatively with performance accuracy. These findings therefore suggest that hyperstimulation of D2 receptors in striatum may contribute to the impairment in visual attention during sleep deprivation. Thus, while dopamine increases in prefrontal regions (including stimulation of D1 receptors) may facilitate attention our findings suggest that hyperstimulation of D2 receptors in striatum may impair it. Alternatively, these associations may reflect a compensatory striatal dopamine response (to maintain arousal) that is superimposed on a larger response to sleep deprivation.
Related Links	http://dx.doi.org/10.1016/j.neuroimage.2009.01.003
Ending Page	1240
Page Count	9
Starting Page	1232
File Format	PDF
ISSN	10538119
e-ISSN	10959572
Journal	NeuroImage
Issue Number	4
Volume Number	45
Language	English
Publisher Date	2009-05-01
Access Restriction	Open
Subject Keyword	Cognitive Neuroscience Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Cognitive Neuroscience

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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