NDLI: Recovery of Skin Barrier Properties after Sonication in Human Subjects

Content Provider	PubMed Central
Author	Gupta, Jyoti Prausnitz, Mark R.
Abstract	The SonoPrep® ultrasonic skin permeation system is used clinically to increase skin permeability for rapid, non-invasive delivery of local anaesthetics. This study tested the hypothesis that sonication can generate a long-lived increase of skin permeability for continuous transdermal drug delivery and diagnostic metabolite extraction. In order to accomplish this, the volar forearm skin of ten healthy adult subjects was sonicated. As a surrogate measure of skin permeability, skin electrical impedance was measured at occluded and non-occluded sites every hour over a period of 48 h. Sonication dramatically increased skin permeability, as demonstrated by a large drop in skin impedance. Under occlusion, sonicated skin remained highly permeable during the entire 42 h period of occlusion, which was followed by an immediate decrease in permeability upon removal of occlusion. Without occlusion, sonicated skin retained elevated permeability throughout the 48 h experiment, but regained its barrier function more quickly. Therefore, sonication can increase skin permeability for prolonged periods of time, especially under the effect of occlusion, and has potential to facilitate continuous transdermal drug delivery and diagnostic metabolite extraction.
Related Links	http://dx.doi.org/10.1016/j.ultrasmedbio.2009.04.001
Ending Page	1408
Page Count	4
Starting Page	1405
File Format	PDF
ISSN	03015629
e-ISSN	1879291X
Journal	Ultrasound in medicine & biology
Issue Number	8
Volume Number	35
Language	English
Publisher Date	2009-08-01
Access Restriction	Open
Subject Keyword	Biophysics Radiological and Ultrasound Technology Radiology Nuclear Medicine and imaging Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Acoustics and Ultrasonics Biophysics Radiological and Ultrasound Technology

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