NDLI: Cirrhotic cardiomyopathy

Please wait, while we are loading the content...

Relation of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels to growth retardation in extrahepatic portal vein obstruction

The influence of preconditioning on metabolic changes in the pig liver before, during, and after warm liver ischemia measured by microdialysis

A case of lamivudine-sensitive de novo acute hepatitis B induced by rituximab with the CHOP regimen for diffuse large B cell lymphoma

Year: 2008, Volume: 3

Year: 2008, Volume: 2

Year: 2007, Volume: 1

Cirrhotic cardiomyopathy

Content Provider	PubMed Central
Author	Wong, Florence
Abstract	Cirrhotic cardiomyopathy is a recently recognized condition in cirrhosis consisting of systolic incompetence under condition of stress, diastolic dysfunction related to altered diastolic relaxation, and electrophysiological abnormalities in the absence of any known cardiac disease. It can be diagnosed by using a combination of electrocardiograph, 2-dimensional echocardiography, and various serum markers such as brain natriuretic factor. The underlying pathogenetic mechanisms include abnormalities in the β-adrenergic signaling pathway, altered cardiomyocyte membrane fluidity, increased myocardial fibrosis, cardiomyocyte hypertrophy, and ion channel defects. Various compounds for which levels are elevated in cirrhosis such as nitric oxide and carbon monoxide can also exert a negative inotropic effect on the myocardium, whereas excess sodium and volume retention can lead to myocardial hypertrophy. Various toxins can also aggravate the ion channel defects, thereby widening the QRS complex causing prolonged QT intervals. Clinically, systolic incompetence is most evident when cirrhotic patients are placed under stress, whether physical or pharmacological, or when the extent of peripheral arterial vasodilatation demands an increased cardiac output as in the case of bacterial infections. Acute volume overload such as immediately after insertion of a transjugular intrahepatic portosystemic shunt or after liver transplantation can also tip these cirrhotic patients into cardiac failure. Treatment of cirrhotic cardiomyopathy is unsatisfactory. There is some evidence that β-blockade may help some cirrhotic patients with baseline prolonged QT interval. Long-term aldosterone antagonism may help reduce myocardial hypertrophy. Future studies should include further elucidation of pathogenetic mechanisms so as to develop effective treatment strategies.
Related Links	http://dx.doi.org/10.1007/s12072-008-9109-7
Ending Page	304
Page Count	11
Starting Page	294
File Format	PDF
ISSN	19360533
e-ISSN	19360541
Journal	Hepatology International
Issue Number	1
Volume Number	3
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-01
Access Restriction	Open
Rights Holder	Springer-Verlag
Subject Keyword	Hepatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Hepatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cirrhotic cardiomyopathy: review of pathophysiology and treatment

Cirrhotic cardiomyopathy: Isn’t stress evaluation always required for the diagnosis?

Cirrhotic cardiomyopathy: Implications for the perioperative management of liver transplant patients

Systolic and diastolic impairment in cirrhotic cardiomyopathy: insights from a cross-sectional study

Cirrhotic cardiomyopathy.

Cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy: review of pathophysiology and treatment.

Laparoscopic Cholecystectomy in Cirrhotic Patient

Cirrhotic cardiomyopathy

Similar Documents

Cirrhotic cardiomyopathy: review of pathophysiology and treatment

Cirrhotic cardiomyopathy: Isn’t stress evaluation always required for the diagnosis?

Cirrhotic cardiomyopathy: Implications for the perioperative management of liver transplant patients

Systolic and diastolic impairment in cirrhotic cardiomyopathy: insights from a cross-sectional study

Cirrhotic cardiomyopathy.

Cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy: review of pathophysiology and treatment.

Laparoscopic Cholecystectomy in Cirrhotic Patient

Cirrhotic cardiomyopathy