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| Content Provider | PubMed Central |
|---|---|
| Author | Roy, Sujit Singh, Sanjay Kumar Choudhury, Swarup Roy Sengupta, Dibyendu N. |
| Copyright Year | 2009 |
| Abstract | Recently we have reported the characterization of a novel single subunit 62-kDa polypeptide with ddNTP-sensitive DNA polymerase activity from the developing seeds of mungbean (Vigna radiata). The protein showed higher expression and activity level during nuclear endoreduplication stages of mungbean seeds and similarity with mammalian DNA polymerase β in many physicochemical properties.1 The enzyme was found to specifically interact with PCNA (proliferating cell nuclear antigen),2 and expressed in both meristematic and meiotic tissues. Functional assays have demonstrated binding of the enzyme to normal and mismatched DNA substrates and with fidelity DNA synthesis in moderately processive mode, suggesting probable involvement of the enzyme in both replication and recombination.3 Here we have discussed the position of mungbean DNA polymerase as a homologue of DNA Pol λ, one of the newly identified member of family-X DNA polymerase in plants and illustrated the functional relevance of this enzyme in maintaining the coordination between DNA replication and repair in plant genome. |
| Starting Page | 678 |
| File Format | |
| ISSN | 15592324 |
| e-ISSN | 15592324 |
| Journal | Plant Signaling & Behavior |
| Issue Number | 7 |
| Volume Number | 4 |
| Language | English |
| Publisher | Landes Bioscience |
| Publisher Date | 2009-07-01 |
| Access Restriction | Open |
| Rights Holder | Landes Bioscience |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
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