NDLI: Gene therapy: Regulations, ethics and its practicalities in liver disease

Content Provider	PubMed Central
Author	Jin, Xi Yang, Yi-da Li, You-ming
Copyright Year	2008
Abstract	Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to the target cells, it could exert functions on the level of genes and molecules. It is hoped to be widely used in the treatment of liver disease, especially hepatic tumors by using different vectors encoding the aim gene for anti-tumor activity by activating primary and adaptive immunity, inhibiting oncogene and angiogenesis. Despite the huge curative potential shown in animal models and some pilot clinical trials, gene therapy has been under fierce discussion since its birth in academia and the public domain because of its unexpected side effects and ethical problems. There are other challenges arising from the technique itself like vector design, administration route test and standard protocol exploration. How well we respond will decide the fate of gene therapy clinical medical practice.
Related Links	http://dx.doi.org/10.3748/wjg.14.2303
Starting Page	2303
File Format	PDF
ISSN	10079327
Journal	World Journal of Gastroenterology : WJG
Issue Number	15
Volume Number	14
Language	English
Publisher	The WJG Press and Baishideng
Publisher Date	2008-01-01
Access Restriction	Open
Rights Holder	The WJG Press and Baishideng
Subject Keyword	Gastroenterology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

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Gene therapy: Regulations, ethics and its practicalities in liver disease