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| Content Provider | PubMed Central |
|---|---|
| Author | Siemsen, Daniel W. Kirpotina, Liliya N. Jutila, Mark A. Quinn, Mark T. |
| Abstract | Coxiella burnetii is an obligate intracellular Gram-negative pathogen. A notable feature of C. burnetii is its ability to replicate within acidic phagolysosomes; however, the mechanisms utilized in evading host defenses are not well defined. Here, we investigated human neutrophil phagocytosis of C. burnetii (Nine Mile, phase II; NMII) and the effect of phagocytosed organisms on neutrophil reactive oxygen species (ROS) production. We found that opsonization with immune serum substantially enhanced phagocytosis of NMII. Human neutrophils phagocytosing opsonized NMII generated very little ROS compared to cells phagocytosing opsonized Staphylococcus aureus, Escherichia coli, or zymosan. However, phagocytosis of NMII did not affect the subsequent ROS response to a soluble agonist, indicating inhibition was localized to the phagolysosome and was not a global effect. Indeed, analysis of NADPH oxidase assembly in neutrophils after phagocytosis showed that translocation of cytosolic NADPH oxidase proteins, p47 phox and p67 phox , to the membrane was absent in cells phagocytosing NMII, as compared to cells phagocytosing S. aureus or activated by phorbol myristate acetate. Thus, phagocytosed NMII is able to disrupt assembly of the human neutrophil NADPH oxidase, which represents a novel virulence mechanism for this organism and appears to be a common mechanism of virulence for many intracellular pathogens. |
| Related Links | http://dx.doi.org/10.1016/j.micinf.2009.04.005 |
| Ending Page | 679 |
| Page Count | 9 |
| Starting Page | 671 |
| File Format | |
| ISSN | 12864579 |
| Journal | Microbes and infection / Institut Pasteur |
| Issue Number | 6-7 |
| Volume Number | 11 |
| Language | English |
| Publisher Date | 2009-05-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Microbiology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology Microbiology |
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