WebSite Logo
  • Content
  • Similar Resources
  • Metadata
  • Cite This
  • Language
    অসমীয়া বাংলা भोजपुरी डोगरी English ગુજરાતી हिंदी ಕನ್ನಡ
    Khasi कोंकणी मैथिली മലയാളം ꯃꯤꯇꯩ ꯂꯣꯟ मराठी Mizo नेपाली
    ଓଡ଼ିଆ ਪੰਜਾਬੀ संस्कृत ᱥᱟᱱᱛᱟᱲᱤ सिन्धी தமிழ் తెలుగు اردو
  • Log-in
  • Fullscreen
Log-in
Do not have an account? Register Now
Forgot your password? Account recovery
  1. Microbes and Infection / Institut Pasteur
  2. Year: 2009, Volume: 11
  3. Year: 2009, Volume: 11, Issue: 6-7
  4. Inhibition of the Human Neutrophil NADPH Oxidase by Coxiella burnetii
Loading...

Please wait, while we are loading the content...

Year: 2015, Volume: 17
Year: 2014, Volume: 16
Year: 2013, Volume: 15
Year: 2012, Volume: 14
Year: 2011, Volume: 13
Year: 2010, Volume: 12
Year: 2009, Volume: 11
Year: 2009, Volume: 11, Issue: 14-15
Year: 2009, Volume: 11, Issue: 12
Year: 2009, Volume: 11, Issue: 10-11
Year: 2009, Volume: 11, Issue: 8-9
Year: 2009, Volume: 11, Issue: 6-7
Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics?
Inhibition of the Human Neutrophil NADPH Oxidase by Coxiella burnetii
Neutralization of TNFα alters inflammation in guinea pig tuberculous pleuritis
Year: 2009, Volume: 11, Issue: 5
Year: 2009, Volume: 11, Issue: 3
Year: 2009, Volume: 11, Issue: 1
Year: 2008, Volume: 10
Year: 2007, Volume: 9
Year: 2006, Volume: 8
Year: 2004, Volume: 6
Year: 2003, Volume: 5
Year: 2001, Volume: 3

Similar Documents

...
Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii.

Article

...
Inhibition of human neutrophil NADPH oxidase by Chlamydia serovars E, K, and L2.

Article

...
Both Inducible Nitric Oxide Synthase and NADPH Oxidase Contribute to the Control of Virulent Phase I Coxiella burnetii Infections

Article

...
Fungal Metabolite Gliotoxin Targets Flavocytochrome b 558 in the Activation of the Human Neutrophil NADPH Oxidase

Article

...
Neutrophil NADPH Oxidase Is Reduced at the Anaplasma phagocytophilum Phagosome

Article

...
Coxiella burnetii Induces Reorganization of the Actin Cytoskeleton in Human Monocytes

Article

...
Reduced Transendothelial Migration of Monocytes Infected by Coxiella burnetii

Article

...
Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii.

Article

...
Coxiella burnetii Inhibits Apoptosis in Human THP-1 Cells and Monkey Primary Alveolar Macrophages▿

Article

Inhibition of the Human Neutrophil NADPH Oxidase by Coxiella burnetii

Content Provider PubMed Central
Author Siemsen, Daniel W. Kirpotina, Liliya N. Jutila, Mark A. Quinn, Mark T.
Abstract Coxiella burnetii is an obligate intracellular Gram-negative pathogen. A notable feature of C. burnetii is its ability to replicate within acidic phagolysosomes; however, the mechanisms utilized in evading host defenses are not well defined. Here, we investigated human neutrophil phagocytosis of C. burnetii (Nine Mile, phase II; NMII) and the effect of phagocytosed organisms on neutrophil reactive oxygen species (ROS) production. We found that opsonization with immune serum substantially enhanced phagocytosis of NMII. Human neutrophils phagocytosing opsonized NMII generated very little ROS compared to cells phagocytosing opsonized Staphylococcus aureus, Escherichia coli, or zymosan. However, phagocytosis of NMII did not affect the subsequent ROS response to a soluble agonist, indicating inhibition was localized to the phagolysosome and was not a global effect. Indeed, analysis of NADPH oxidase assembly in neutrophils after phagocytosis showed that translocation of cytosolic NADPH oxidase proteins, p47 phox and p67 phox , to the membrane was absent in cells phagocytosing NMII, as compared to cells phagocytosing S. aureus or activated by phorbol myristate acetate. Thus, phagocytosed NMII is able to disrupt assembly of the human neutrophil NADPH oxidase, which represents a novel virulence mechanism for this organism and appears to be a common mechanism of virulence for many intracellular pathogens.
Related Links http://dx.doi.org/10.1016/j.micinf.2009.04.005
Ending Page 679
Page Count 9
Starting Page 671
File Format PDF
ISSN 12864579
Journal Microbes and infection / Institut Pasteur
Issue Number 6-7
Volume Number 11
Language English
Publisher Date 2009-05-01
Access Restriction Open
Subject Keyword Immunology Microbiology Infectious Diseases Research in Higher Education
Content Type Text
Resource Type Article
Subject Infectious Diseases Immunology Microbiology
  • About
  • Disclaimer
  • Feedback
  • Sponsor
  • Contact
About National Digital Library of India (NDLI)
NDLI logo

National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.

Learn more about this project from here.

Disclaimer

NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.

Feedback

Sponsor

Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.

Contact National Digital Library of India
Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302
See location in the Map
03222 282435
Mail: support@ndl.gov.in
Sl. Authority Responsibilities Communication Details
1 Ministry of Education (GoI),
Department of Higher Education
Sanctioning Authority https://www.education.gov.in/ict-initiatives
2 Indian Institute of Technology Kharagpur Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project https://www.iitkgp.ac.in
3 National Digital Library of India Office, Indian Institute of Technology Kharagpur The administrative and infrastructural headquarters of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
4 Project PI / Joint PI Principal Investigator and Joint Principal Investigators of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
Prof. Saswat Chakrabarti  will be added soon
5 Website/Portal (Helpdesk) Queries regarding NDLI and its services support@ndl.gov.in
6 Contents and Copyright Issues Queries related to content curation and copyright issues content@ndl.gov.in
7 National Digital Library of India Club (NDLI Club) Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach clubsupport@ndl.gov.in
8 Digital Preservation Centre (DPC) Assistance with digitizing and archiving copyright-free printed books dpc@ndl.gov.in
9 IDR Setup or Support Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops idr@ndl.gov.in
Cite this Content
Loading...